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Diss Factsheets
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EC number: 856-663-9 | CAS number: 2400970-89-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 July 2020 thru 19 August 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Carbamodithioic acid, bis(mixed 2-ethylhexyl and 2-methylbutyl and pentyl) derivs., antimony (3+) salts
- Molecular formula:
- C33H66N3S6Sb to C51H102N3S6Sb
- IUPAC Name:
- Carbamodithioic acid, bis(mixed 2-ethylhexyl and 2-methylbutyl and pentyl) derivs., antimony (3+) salts
- Test material form:
- liquid: viscous
Constituent 1
- Specific details on test material used for the study:
- PYSICAL DESCRIPTION: Highly viscous amber liquid.
PURITY: >99%
SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material: WT05-19
- Expiration date of the lot/batch: not applicable
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temp.
- Stability under storage conditions: stable for the duration of testing.
Test animals / tissue source
- Details on test animals or tissues and environmental conditions:
- EpiOcular tissue construct designed to medel the cornea epithelium with progressively stratified, but non-cornified cells.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- 50 micro-liters
- Duration of treatment / exposure:
- 30 min
- Duration of post- treatment incubation (in vitro):
- 2 hours
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- - RhCE tissue construct used, including batch number
: MatTek Corporation EpiOcular EIT MK-24-007-0055, released 02/10/2017
- Negative Control: deionized water
- Positive Control: methyl acetate
- Doses of test chemical and control substances used : 50 micro-liters
- Optical density (OD) was read in a 96-well plate spectrophotometer using a wavelength of 570 nm without using a reference filter
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Run / experiment:
- Average Viability (%)
- Value:
- 82.6
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
Substance |
Average Optical Density Reading |
SD (Optical Density) |
Average % Viability |
SD (Viability) |
Irritant/ |
GHS Category |
Test Item |
1.883 |
0.014 |
82.6[1] |
0.61 |
Non Irritant |
No Category |
Freeze Killed - Test Article |
0.299 |
0.038 |
13.1 |
1.67 |
- |
- |
Freeze Killed – Negative Control |
0.041 |
0.001 |
1.8 |
0.03 |
- |
- |
Negative Control (deionized water) |
2.279 |
0.049 |
100.0 |
2.14 |
Non Irritant |
No Category |
Positive Control (methyl acetate) |
0.888 |
0.167 |
39.0 |
7.32 |
Irritant |
2 |
[1]The corrected % viability of the test article was calculated to be 71.285%.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item was not an eye irritant in the in vitro EpiOcular reconstructed human cornea-like epithelium (RhCE) Eye Irritation Test.
- Executive summary:
In an OECD Method 492 Guideline study conducted under GLP conditions using the in vitro EpiOcular reconstructed human cornea-like epithelium (RhCE) Eye Irritation Test, the test item did not produce a significant irritation response. Average viability of the tissue was 82.6% (corrected to 71.285%) following treatment with the test item.
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