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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The BCF 28 days was <61 and ≤ 53 L/kg at the concentration of 0.02 and 0.2 µg/L, respectively. Pergafast 425 was not considered to be bioaccumulative since the BCF is < 2000 L/kg.
Key value for chemical safety assessment
Additional information
A bioconcentration study was conducted according to OECD guideline 305-I: aqueous exposure bioconcentration fish test and GLP principles. The fish were exposed to a concentration of 0.02 and 0.2 µg/L and a solvent control. Samples of the test water and fish were taken on several time points during the uptake phase to determine the stability of the test item in the water and the concentration of test item in fish tissue. At the exposure concentration of 0.02 µg/L, the concentration of test item in fish tissue was below the LOQ (1.3 ng/g fish). At the concentration of 0.2 µg/L, the average test item concentrations were over ±20% in the test fish samples taken at day 14, 20, 26 and 28. The average concentrations in fish tissue were 5.9, 6.6, 11, 6.0 ng/g fish on day 14, 20, 26 and 28, respectively. No steady state BCF could be determined since the concentration in fish sample was below the LOQ or the variation of the test item concentration was >20%. The BCF after 28 day was set to be <61 L/kg and ≤ 53 L/kg at the nominal concentration of 0.02 and 0.2 µg/L, respectively. Since the BCF of the test item was below 100 L/kg, a depuration phase was not conducted and the kinetic BCF values and the half life time values were not determined. Pergafast 425 was not considered to be bioaccumulative since the BCF is < 2000 L/kg. The validity criteria of the study were met and therefore the study is considered to be valid without restrictions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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