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EC number: 951-963-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- transformation / dissolution of metals and inorganic metal compounds
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 Nov 2019 - 04 Mar 2020
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media
- GLP compliance:
- yes
- Type of method:
- other: This study was performed in order to determine the transformation and/or dissolution of Sulphide Precipitate via measurement of Zink (Zn) per ICP-OES in aqueous media.
- Specific details on test material used for the study:
- Name Sulphide Precipitate
Batch no. 20190601
Appearance blackish-green, wet sticky solid
Composition 2.9 % Cu; 18.0 % Zn; 0.5 % Fe; 0.1 % Pb; 0.7 % Cd; 0.4 % As; 0.3 % Sb; 0.1 % Sn; 0.0 % Bi; 0.0 % Br; 2.7 % Cl; 1.1 % F
CAS No. unknown
EC-No. 951-963-7
Molecular formula not stated
Molecular weight not stated
Purity 100 % (UVCB)
Homogeneity homogeneous
Vapour pressure not stated
Stability in solvents H2O: not stated; EtOH: not stated; acetone: not stated; CH3CN: not stated; DMSO: not stated
Solubility in solvents H2O: not stated; EtOH: not stated; acetone: not stated; CH3CN: not stated; DMSO: not stated
Production date not stated
Expiry date 31. Dec. 2025
Storage room temperature (20 ± 5 °C)
Stability stable under storage conditions - Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 160 µg/L
- Element analysed:
- Zn
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- Mean value from days 1, 4 and 7.
- Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 1 388 µg/L
- Element analysed:
- Zn
- Loading of aqueous phase:
- 10 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- Mean values from days 1, 4 and 7.
- Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 11 056 µg/L
- Element analysed:
- Zn
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- Men values from days 1, 4 and 7.
- Details on results:
- The following mean vales and RSD were calculated:
Analysis Data for Zn (Flasks 3 – 5, 1 mg/L)
Flask # Conc. after 2 h [µg/L] Conc. after 6 h [µg/L] Conc. after 1 d [µg/L] Conc. after 4 d [µg/L] Conc. after 7 d [µg/L]
3 118.9 136.4 152.3 141.6 127.5
4 129.1 159.4 186.7 166.6 155.0
5 128.9 165.4 188.8 169.9 156.9
Mean 125.6 153.7 175.9 159.3 146.5
RSD [%] 4.6 10.0 11.7 9.7 11.2
Analysis Data for Zn (Flasks 6 – 8, 10 mg/L)
Flask # Conc. after 2 h [µg/L] Conc. after 6 h [µg/L] Conc. after 1 d [µg/L] Conc. after 4 d [µg/L] Conc. after 7 d [µg/L]
6 1181 1309 1497 1395 1271
7 1266 1433 1622 1462 1358
8 715.8 933.1 1200 1368 1322
Mean 1054 1225 1440 1408 1317
RSD [%] 28.1 21.2 15.0 3.4 3.3
Analysis Data for Zn (Flasks 9 – 11, 100 mg/L)
Flask # Conc. after 2 h [µg/L] Conc. after 6 h [µg/L] Conc. after 1 d [µg/L] Conc. after 4 d [µg/L] Conc. after 7 d [µg/L]
9 6333 9081 11691 10300 10202
10 6197 8613 11498 10562 10410
11 6518 9313 12315 11244 11283
Mean 6350 9002 11835 10702 10631
RSD [%] 2.5 4.0 3.6 4.6 5.4 - Conclusions:
- The following concentrations of Zn were stated as a mean value from days 1, 4 and 7:
1 mg/L 160.6 µg/L;
10 mg/L 1388 µg/L;
100 mg/L 11056 µg/L. - Executive summary:
In this study, the maximum concentration of total dissolved Zink was determined in order to identify compounds of Sulphide Precipitate which undergo either dissolution or rapid transformation.
The calibration was performed using a certified Zn stock solution (1000 mg/L nominal each). All validation conditions for the range of 1 – 100 µg/L Zn in pH 5.5 buffer solution were fulfilled.During the study the calibration was performed two times in pH 5.5 buffer solution as the first calibration was invalid. Therefore, the data of calibration 2 were presented in the final report only. As the accuracy in pH 8.5 buffer solution lay outside the range of 70 – 110 %, the calibration (3) was additionally performed in pH 8.5 buffer solution.
The correlation coefficient r was > 0.99 of each calibration.The back calculated concentrations of the calibration standards layin the demanded ranges 100 ± 15 % and 100±20 % (low concentration) of the nominal values of each calibration. The accuracy in pH 7.0 buffer solution lay in the range of 70 – 110 % only. For the determination of Zn in pH 7.0 buffer solution the recovery rate 80.6 % was taken into account in the calculation of Zn concentration in the screening test. For the determination of Zn in pH 8.5 buffer solution, the calibration was additionally performed in pH 8.5 buffer solution and this calibration function was used for calculation of Zn concentration in pH 8.5 buffer during the screening test.
After the screening test, pH 5.5 was chosen for the reproducibility and full test based on the highest measured concentrations of Zn. The reproducibility test was performed with 100 mg/L test item (nominal) in pH 5.5 buffer solution over a period of 24 hours. Five vessels were prepared; each flask was measured in triplicate. A within-vessel variation of max. 10% and a between-vessel variation of max. 20% is demanded. These conditions were fulfilled. Therefore, for the full test three flasks per concentration with double determination were used.
The full test was performed with three different concentrations of the test item (nominal loads 1, 10 and 100 mg/L, three replicates each) over a period of 7 days with samplings after 2 h, 6 h, 1 d, 4 d and 7 d. Two flasks were prepared as blanks without addition of test item. No linear dependency of measured concentrations on time was observed for each nominal load. As the result a mean value of days 1, 4 and 7 was stated.
The pH values in the flasks 1 – 5 (blanks and 1 mg/L nominal concentration) lay in the demanded range 5.5±0.2 during the whole full test. The pH value in the flasks 6 – 8 and 9 – 11 lay in the range of 5.60 – 6.07 and 6.01 – 6.29 after addition of the test item, respectively. The adjustment of the pH value in the demanded range of 5.5±0.2 (flasks 9 – 11) was unsuccessful during the whole test as test item has changed the pH value.
The conditions RSD < 10 % (within-vessel)and < 20 % (between-vessel) were fulfilled in all flasks at each sampling point except the RSD between 6 – 8 flasks after 2 and 6 h. This was considered as uncritical as the result of dissolution of Zn with 10 mg/L nominal load was stated as a mean value of days 1 – 7.
No linear dependency of measured concentrations on time was observed. Usage of the first order model was also not possible for the determination of kinetic as the equilibrium was observed after 24 h. Two sampling points (2 h and 6 h) are not enough for calculation of kinetic. Therefore, the determination of kinetic was not possible.
The mass balance lay in the range of 66.6 – 82.3 %.The difference is possible a result of the dissolution of another compounds of the test item (UVCB) which were not analyzed during the study.
Reference
A duplicate determination was performed from each flask. Measurement data for Zn are presented in the following table:
Fl. |
Content |
Conc.Znin µg/L at following sampling points |
|||||
0 h1 |
2 h |
6 h |
1 d |
4 d |
7 d |
||
1 |
blank |
< 1 |
< 1 |
2.77 |
8.40 |
5.58 |
6.90 |
< 1 |
< 1 |
2.03 |
4.62 |
5.71 |
6.97 |
||
2 |
blank |
< 1 |
< 12 |
1.02 |
< 1 |
< 1 |
1.24 |
< 1 |
< 1 |
< 1 |
< 1 |
< 1 |
< 1 |
||
3 |
1.0 mg/L |
< 12 |
117.8 |
136.4 |
151.8 |
145.0 |
128.0 |
< 1 |
120.0 |
136.3 |
152.8 |
138.1 |
127.0 |
||
4 |
1.0 mg/L |
< 1 |
134.6 |
158.8 |
186.73 |
166.7 |
151.6 |
< 1 |
123.6 |
160.0 |
186.73 |
166.5 |
158.5 |
||
5 |
1.0 mg/L |
< 1 |
127.9 |
163.2 |
191.5 |
171.5 |
157.0 |
< 1 |
129.9 |
167.5 |
186.2 |
168.3 |
156.9 |
||
6 |
10 mg/L |
< 1 |
1238 |
1302 |
1499 |
1337 |
1268 |
< 1 |
1124 |
1317 |
1495 |
1454 |
1274 |
||
7 |
10 mg/L |
< 12 |
1325 |
1425 |
1625 |
1464 |
1357 |
< 1 |
1206 |
1440 |
1618 |
1459 |
1358 |
||
8 |
10 mg/L |
< 1 |
716.5 |
943.4 |
1200 |
1370 |
1320 |
< 1 |
715.2 |
922.9 |
1201 |
1367 |
1324 |
||
9 |
100 mg/L |
< 12 |
6288 |
9045 |
11751 |
< 14 |
10193 |
< 1 |
6379 |
9118 |
11631 |
10300 |
10210 |
||
10 |
100 mg/L |
< 1 |
6013 |
8582 |
11484 |
10532 |
10405 |
< 12 |
6382 |
8644 |
11512 |
10592 |
10414 |
||
11 |
100 mg/L |
< 12 |
6510 |
9327 |
12351 |
11241 |
11261 |
< 1 |
6527 |
9298 |
12279 |
11248 |
11305 |
1the LOQ of Zn is 1 µg/L
2second measurementas a contamination was observed during the first measurement (2-4 µg/L Zn)
3repetition of the measurement as an error was observed during the sample preparation
4 error during the sample preparation
Slightly contamination was observed in the flask 1 (blank solution).
Description of key information
The following concentrations of Zn were stated as a mean value from days 1, 4 and 7:
1 mg/L 160.6 µg/L;
10 mg/L 1 388 µg/L;
100 mg/L 11 056 µg/L.
Key value for chemical safety assessment
- Water solubility:
- 11 mg/L
- at the temperature of:
- 21 °C
Additional information
In this study, the maximum concentration of total dissolved Zink was determined in order to identify compounds of Sulphide Precipitate which undergo either dissolution or rapid transformation.
The calibration was performed using a certified Zn stock solution (1000 mg/L nominal each). All validation conditions for the range of 1 – 100 µg/L Zn in pH 5.5 buffer solution were fulfilled.During the study the calibration was performed two times in pH 5.5 buffer solution as the first calibration was invalid. Therefore, the data of calibration 2 were presented in the final report only. As the accuracy in pH 8.5 buffer solution lay outside the range of 70 – 110 %, the calibration (3) was additionally performed in pH 8.5 buffer solution.
The correlation coefficient r was > 0.99 of each calibration.The back calculated concentrations of the calibration standards layin the demanded ranges 100 ± 15 % and 100±20 % (low concentration) of the nominal values of each calibration. The accuracy in pH 7.0 buffer solution lay in the range of 70 – 110 % only. For the determination of Zn in pH 7.0 buffer solution the recovery rate 80.6 % was taken into account in the calculation of Zn concentration in the screening test. For the determination of Zn in pH 8.5 buffer solution, the calibration was additionally performed in pH 8.5 buffer solution and this calibration function was used for calculation of Zn concentration in pH 8.5 buffer during the screening test.
After the screening test, pH 5.5 was chosen for the reproducibility and full test based on the highest measured concentrations of Zn. The reproducibility test was performed with 100 mg/L test item (nominal) in pH 5.5 buffer solution over a period of 24 hours. Five vessels were prepared; each flask was measured in triplicate. A within-vessel variation of max. 10% and a between-vessel variation of max. 20% is demanded. These conditions were fulfilled. Therefore, for the full test three flasks per concentration with double determination were used.
The full test was performed with three different concentrations of the test item (nominal loads 1, 10 and 100 mg/L, three replicates each) over a period of 7 days with samplings after 2 h, 6 h, 1 d, 4 d and 7 d. Two flasks were prepared as blanks without addition of test item. No linear dependency of measured concentrations on time was observed for each nominal load. As the result a mean value of days 1, 4 and 7 was stated.
The pH values in the flasks 1 – 5 (blanks and 1 mg/L nominal concentration) lay in the demanded range 5.5±0.2 during the whole full test. The pH value in the flasks 6 – 8 and 9 – 11 lay in the range of 5.60 – 6.07 and 6.01 – 6.29 after addition of the test item, respectively. The adjustment of the pH value in the demanded range of 5.5±0.2 (flasks 9 – 11) was unsuccessful during the whole test as test item has changed the pH value.
The conditions RSD < 10 % (within-vessel)and < 20 % (between-vessel) were fulfilled in all flasks at each sampling point except the RSD between 6 – 8 flasks after 2 and 6 h. This was considered as uncritical as the result of dissolution of Zn with 10 mg/L nominal load was stated as a mean value of days 1 – 7.
No linear dependency of measured concentrations on time was observed. Usage of the first order model was also not possible for the determination of kinetic as the equilibrium was observed after 24 h. Two sampling points (2 h and 6 h) are not enough for calculation of kinetic. Therefore, the determination of kinetic was not possible.
The mass balance lay in the range of 66.6 – 82.3 %.The difference is possible a result of the dissolution of another compounds of the test item (UVCB) which were not analyzed during the study.
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