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EC number: 203-867-5 | CAS number: 111-41-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(2-aminoethylamino)ethanol
- EC Number:
- 203-867-5
- EC Name:
- 2-(2-aminoethylamino)ethanol
- Cas Number:
- 111-41-1
- Molecular formula:
- C4H12N2O
- IUPAC Name:
- 2-[(2-aminoethyl)amino]ethan-1-ol
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M. GAUKLER, 6050 Offenbach
- Age at study initiation: not indicated
- Weight at study initiation: 4- hour exposure: ca 3.1 kg; 1 hour exposure 3.0 kg.
- Housing: not indicated
- Diet: Ssniff K, INTERMAST GMBH, Soest, ad libitum (no food during exposure)
- Water: Ad libitum
- Acclimation period: not indicated
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied : 0.5 mL test item - Duration of treatment / exposure:
- 4 hours and 1 hour treatment period
- Observation period:
- 8 days
- Number of animals:
- 4 Hours test: 2 males
1 Hour test: 2 males and 2 females - Details on study design:
- TEST SITE
- Area of exposure: 2 * 2 cm on the backsite of the rabbit.
- % coverage: covered with a linnen cloth, fixated with an adhesive bandage (semi-occlusive)
REMOVAL OF TEST SUBSTANCE
- Washing: Washing with Lutrol/water-mix (1:1)
- Time after start of exposure: 4 hours or 1 hour.
OBSERVATION TIME POINTS
Observations were made directly after the removal of the test item, and on one, two and 8 days after removal of the test item.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 1 Hour exposure
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Remarks on result:
- other:
- Remarks:
- Slight necrosis
- Irritation parameter:
- erythema score
- Remarks:
- 1 Hour exposure
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 4
- Max. score:
- 4
- Remarks on result:
- other: Necrosis and dry skin
- Irritation parameter:
- erythema score
- Remarks:
- 1 hour exposure
- Basis:
- animal #1
- Time point:
- other: 8d
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Leathery Necrosis
- Irritation parameter:
- erythema score
- Remarks:
- 1 Hour exposure
- Basis:
- animal #2
- Time point:
- 24/48 h
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Remarks:
- 1 Hour exposure
- Basis:
- animal #2
- Time point:
- other: 8d
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Remarks:
- 1 Hour exposure
- Basis:
- animal #3
- Time point:
- 24/48 h
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Remarks:
- 1 Hour exposure
- Basis:
- animal #3
- Time point:
- other: 8d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8d
- Remarks on result:
- other: peeling of the skin
- Irritation parameter:
- erythema score
- Remarks:
- 1 Hour exposure
- Basis:
- animal #4
- Time point:
- other: 24h/48h/8d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24h
- Irritation parameter:
- edema score
- Remarks:
- 1 Hour exposure
- Basis:
- animal #1
- Time point:
- 24/48 h
- Score:
- 1
- Max. score:
- 4
- Irritation parameter:
- edema score
- Remarks:
- 1 Hour exposure
- Basis:
- animal #1
- Time point:
- other: 8d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8d
- Irritation parameter:
- edema score
- Remarks:
- 1 Hour exposure
- Basis:
- animal #2
- Time point:
- 24/48 h
- Score:
- 1
- Max. score:
- 4
- Irritation parameter:
- edema score
- Remarks:
- 1 Hour exposure
- Basis:
- animal #2
- Time point:
- other: 8d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8d
- Irritation parameter:
- edema score
- Remarks:
- 1 Hour exposure
- Basis:
- animal #3
- Time point:
- other: 24h/48h/8d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8d
- Irritation parameter:
- edema score
- Remarks:
- 1 Hour exposure
- Basis:
- animal #4
- Time point:
- other: 24h/48h8d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24h
- Irritant / corrosive response data:
- Irritation paratmeters directly after 1 hour exposure:
- Erytherma; one animal showed strong erythema (score 3, animal #1) and three animals showed light erythema (score 2).
- Edema: All animals showed light edema (score 2).
- Corrosive response; One aminal showed necrosis, not reversible within 8 days. One animal showed peeling of the skin 8d after exposure.
Results of the 4 Hour exposure: See attachtted table in "attached documents"
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Based on these results aminoethylethanolamin is considered to be corrosive.
- Executive summary:
A skin irrtitation test was performed with Aminoäthyläthanolamin-S. The test item was applied undiluted (0.5 mL) directly on top of the shaved skin tissue for 1 hour(4 animals) or 4 hours (two animals). Directly after the exposure period and 1, 2 and 8 days after the exposure period the skin was examined for irritating and corrosive effects.
Severe necrosis was observed after exposure to Aminoäthyläthanolamin-S for 1 hour and 4hours.
Based on these results the test chemical is considered to be corrosive Catogory 1 based on GHS citeria.
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