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Diss Factsheets
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EC number: 855-228-0 | CAS number: 4497-59-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 Jul - 21 Aug 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- GLP compliance unknown, minor deviations from guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Version / remarks:
- adopted 17 Dec 2001
- Deviations:
- yes
- Remarks:
- - Animals should be 8-12 weeks old, but were 7 weeks old - No information on sighting study
- GLP compliance:
- not specified
- Remarks:
- in-house safety study
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- 1-(2,2,4-trimethyl-3,4-dihydroquinolin-l (2H)-yl)ethanone
- EC Number:
- 855-228-0
- Cas Number:
- 4497-59-0
- Molecular formula:
- C14 H19 N O
- IUPAC Name:
- 1-(2,2,4-trimethyl-3,4-dihydroquinolin-l (2H)-yl)ethanone
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories Japan Inc.
- Age at study initiation: 7 weeks
- Weight at study initiation: 147 - 178 g
- Fasting period before study: Animals were fasted 20 h prior to administration and 4 h after.
- Housing: 2 - 3 animals per cage in aluminium cages
- Diet: solid mouse and rat chow (CRF-1, Oriental Yeast Co., Ltd.); ad libitum (besides fasting period)
- Water: filter-treated Osaka municipal tap water automatic water drinking device; ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 - 26
- Humidity (%): 40 - 70
- Air changes (per hr): ≥ 10
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- methylcellulose
- Remarks:
- 0.5% methylcellulose aqueous solution
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
- Doses:
- 300 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed 10 and 30 minutes and 1, 2 and 4 hours after administration and once daily thereafter, for 14 days. Individual body weights were determined immediately before administration, 7 and 14 days after administration, and in the event of being discovered dead.
- Necropsy: Performed at the end of the observation period and in the event of being discovered dead.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000
- Based on:
- test mat.
- Remarks on result:
- other: No statistics were applied to determine an exact LD50.
- Mortality:
- 300 mg/kg bw: No deaths occurred.
2000 mg/kg bw: 3 animals were found dead 2 days after administration (cumulative
mortality 3/5). - Clinical signs:
- other:
- Gross pathology:
- 300 mg/kg bw: No effect attributable to administration of the test substance occurred.
2000 mg/kg bw: No effect attributable to administration of the test substance was noted in the surviving animals. Among the animals which died, retention of gas in the stomach was seen in 1 animal, and retention of liquid in the stomach and scattered reddened foci in the mucosa of the glandular stomach were noted in 2 animals each.
Applicant's summary and conclusion
- Interpretation of results:
- other: Acute Oral 4 (H302) according to Regulation (EC) No 1272/2008
- Conclusions:
- In this acute oral toxicity study in rats a LD50 value of 300 - 2000 mg/kg bw was determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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