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EC number: 612-177-7 | CAS number: 61596-96-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles with acceptable restrictions (limited documentation, e.g. no details about test substance)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
- Principles of method if other than guideline:
- Skin irritation was tested using an internal standardized test method (BASF test).
White Vienna rabbits were used. Usually, two animals were treated for 1, 5, 15 minutes and for 20 hours using occlusive conditions. An application site of 2.5x2.5 cm was covered with the liquid test substance. After the application times (1, 5 and 15 min) the skin was washed with Lutrol solution (50%). The animals were observed for 8 days and skin changes were recorded daily. The report describes findings after 24 hours and at the end of the observation period (8 days). For a final evaluation, the findings after 48 and 72 hours from the raw data were taken into account. - GLP compliance:
- no
Test material
- Reference substance name:
- Hydroxyethylated 2-butyne-1,4-diol
- EC Number:
- 608-711-3
- Cas Number:
- 32167-31-0
- Molecular formula:
- C4 H6 O2 (C2 H4 O) n, where 1 < n < 4.5
- IUPAC Name:
- Hydroxyethylated 2-butyne-1,4-diol
- Details on test material:
- - Name of test material (as cited in study report): Golpanol BEO = Golpanol SC 9189
- Physical state: liquid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3.45 kg (male 1), 2.64 kg (male 2)
ENVIRONMENTAL CONDITIONS
- not reported
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): presumably 1 mL - Duration of treatment / exposure:
- 1 min, 5 min, 15 min and 20 hours
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- Since irritation data are recommended for a 4 h skin exposition, results of the available 20 h and the 15 min exposition will serve as approximation.
TEST SITE
- Area of exposure: The application site of 2.5 X 2.5 cm at the upper third of the back was covered with a cotton cloth loaded with the undiluted liquid (37°C; approx. 1 mL)
REMOVAL OF TEST SUBSTANCE
- Washing: washing was done in the 1 min, 5 min and 15 min test directly after exposure. Lutrol 50% (mild detergent) was used.
No washing was done after the 20 hours treatment.
SCORING
Descriptive scores of the raw data have been converted to Draize numerical scores.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- (20-hour application)
- Basis:
- mean
- Remarks:
- out of 2 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Remarks on result:
- other: There are no data about 72 h. Due to not any irritating effects at 24 and 48 hour reading time point, the value for the 72 hour reading time point was extrapolated and considered to be 0.
- Irritation parameter:
- edema score
- Remarks:
- (20-hour application)
- Basis:
- mean
- Remarks:
- out of 2 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Remarks on result:
- other: There are no data about 72 h. Due to not any irritating effects at 24 and 48 hour reading time point, the value for the 72 hour reading time point was extrapolated and considered to be 0.
- Irritant / corrosive response data:
- After 20 hours treatment no irritant effects were determined at reading times of 24, 48 hours and the end of the observation period of 6 days.
- Other effects:
- No other effects observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
EU: not classified - Executive summary:
Skin irritation was tested using an internal standardized test method (BASF test).
Two white Vienna rabbits were treated for 1, 5, 15 minutes and for 20 hours using occlusive conditions. A shaved application site of 2.5x2.5 cm was covered with the liquid test substance. After the application times (1, 5, 15 min and 20 hours) the skin was washed with Lutrol solution (50%). The animals were observed for 8 days and skin changes were recorded daily. The report describes findings after 24 hours and at the end of the observation period (8 days). For a final evaluation, the findings after 48 and 72 hours from the raw data were taken into account. There are no data about 72 h. Due to not any irritating effects at 24 and 48 hour reading time point, the value for the 72 hour reading time point was extrapolated and considered to be 0. After 20 hours treatment no irritant effects were determined at reading times of 24, 48 hours and the end of the observation period of 6 days.
According to the conditions of the test, the test substance has not to be classified as irritant to the skin.
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