3-Ethoxy-4,6-difluoro-7-pentoxy-dibenzothiophene

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-11-08

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Deviations:

no

GLP compliance:

no

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Percentile:

D10

Mean:

76.6 µm

St. dev.:

7.7

Key result

Percentile:

D50

Mean:

290.9 µm

St. dev.:

5.2

Percentile:

D90

Mean:

1 078.6 µm

St. dev.:

81.6

Individual results

The test item consisted of crystalline particles which appeared agglomerated. The test item was tested as a liquid dispersion in demineralized water (with 1 % detergent). Before the measurement the test item was mixed with demineralized water (with 1 % detergent) and homogenised. This homogenised dispersion was fed to the sample unit, which was filled with demineralized water (with 1 % detergent). Subsequently the diluted dispersion was pumped to the optical system. After passing the analyser beam the sample was pumped back into the small volume sample dispersion unit. After adjusting the laser, measuring the background (demineralized water with 1 % detergent) and adjusting the correct particle concentration (obscuration) the measurement was started. The control software automatically performed three measurements. The average of these three measurements was given as result. Two test series of three measurements each were performed. The measurement time was 12 s.

The median particle size D50 deduced from these distributions were:

1st test series: D50 = 287.2 µm, 2nd test series: D50 = 294.6 µm. The average of the median particle size D50 was D50 = 290.9 µm.

The particle size D10 deduced from these distributions were:

1st test series: D10 = 82.1 µm, 2nd test series: D10 = 71 .2 µm. The average of the particle size 10 was: 76.6 µm.

The particle size D90 deduced from these distributions were:

1st test series: D90 = 1020.9 µm, 2nd test series: D90 = 1 136.3 µm. The average of the particle size D90 was = 1078.6 µm.

The maximum was observed at approximately 250 µm. Additionally shoulders were observed below 10 µm and at approximately 30 µm and 1000 µm.

Conclusions:

The median particle sizes D10, D50 and D90 were determined to be 71.2 µm, 290.9 µm and 1078.6 µm, respectively.

Executive summary:

A study was conducted according to OECD TG 110, CIPAC MT 187 and ISO 13320 to determine the particle size distribution of the test item. The test item consisted of transparent spherical particles. Before the measurement two spatula points of the test item were mixed with demineralized water (with 1 % detergent) and homogenised. This homogenised dispersion was fed to the sample unit, which was filled with distilled water (with 1 % detergent). Subsequently the diluted dispersion was pumped to the optical system. After passing the analyser beam the sample was pumped back into the small volume sample dispersion unit. Two test series of three measurements each were performed. The measurement time was 12 s. The median particle sizes D10, D50 and D90 were determined to be 71.2 µm, 290.9 µm and 1078.6 µm, respectively.

Description of key information

The median particle sizes D10, D50 and D90 were determined to be 71.2 µm, 290.9 µm and 1078.6 µm, respectively.

Additional information

A study was conducted according to OECD TG 110, CIPAC MT 187 and ISO 13320 to determine the particle size distribution of the test item (reference 4.5 -1). The test item consisted of transparent spherical particles. Before the measurement two spatula points of the test item were mixed with demineralized water (with 1 % detergent) and homogenised. This homogenised dispersion was fed to the sample unit, which was filled with distilled water (with 1 % detergent). Subsequently the diluted dispersion was pumped to the optical system. After passing the analyser beam the sample was pumped back into the small volume sample dispersion unit. Two test series of three measurements each were performed. The measurement time was 12 s. The median particle sizes D10, D50 and D90 were determined to be 71.2 µm, 290.9 µm and 1078.6 µm, respectively.