Dipotassium 3,4,5,6-tetrabromophthalate

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

48 hours

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

EPA review document covering tetrabromophthalates.
Substance in test was the anhydride, but this hydrolyses rapidly in water to the acid.
This is considered a valid substitute for read-across as the potassium salt will quickly dissociate; when diluted in solution, both the potassium salt and acid will combine with Calcium and Magnesium ions in natural water and form poorly soluble salts.

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

1999

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

EPA OPPTS 850.1010 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)

Principles of method if other than guideline:

Full details of method not preovided in the review, but noted to be in accordance with national guidelines

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Tetrabromophthalic acid

Cas Number:

13810-83-8

Molecular formula:

C8H2Br4O4

IUPAC Name:

Tetrabromophthalic acid

Specific details on test material used for the study:

Substance in test was an alkyl ester, shown to react in light to quickly hydrolyse in water to the acid. The data relates to the acid form.
Bis(2-ethylhexyl) tetrabromophthalate, EC 247-426-5 hydrolysis shows rapid degradation to tetrabromophthalic acid ( Source: European Chemicals Agency, http://echa.europa.eu/)

This is considered a valid substitute for read-across as the potassium salt will quickly dissociate; when diluted in solution, both the potassium salt and acid will combine with Calcium and Magnesium ions in natural water and form poorly soluble salts.

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test conditions

Hardness:

Not specified, but performed within guidline parameters

Test temperature:

Not specified, but performed within guidline parameters

pH:

Non-adjusted

Reference substance (positive control):

not specified

Results and discussion

Effect concentrations

Duration:

48 h

Dose descriptor:

EC0

Effect conc.:

> 5.6 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Details on results:

There was no reported effect at limit of solubility
Substance in test was the anhydride, but this hydrolyses rapidly in water to the acid.
This is considered a valid substitute for read-across as the potassium salt will quickly dissociate; when diluted in solution, both the potassium salt and acid will combine with Calcium and Magnesium ions in natural water and form poorly soluble salts.

Applicant's summary and conclusion

Conclusions:

Substance in test was the anhydride, but this hydrolyses rapidly in water to the acid.
This is considered a valid substitute for read-across as the potassium salt will quickly dissociate; when diluted in solution, both the potassium salt and acid will combine with Calcium and Magnesium ions in natural water and form poorly soluble salts.