Registration Dossier
Registration Dossier
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EC number: 443-800-9 | CAS number: 40031-31-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance does not meet the criteria for classification as acute toxicity or STOT SE by the oral route and no systemic effects have been observed in in vivo studies with dermal exposure (e.g. skin irritation, skin sensitisation)
- Justification for type of information:
- The acute oral median lethal dose (LD50) of the test material in the Sprague-Dawley strain rat was found to be greater than 2000 mg/kg bodyweight.
There were no deaths.
No signs of systemic toxicity were noted during the study.
All animals showed expected gain in bodyweight during the study.
No abnormalities were noted at necropsy.
The test material when applied as a 20% aqueous dilution produced a primary irritation index of 0.0 and was classified as a NON-IRRITANT to rabbit skin according to the Draize cl assification scheme. No corrosive effects were noted.
No corneal or iridial effects were noted during the study.
Minimal conjunctiva 1 irritation was noted in one treated eye one hour after treatment.
All treated eyes appeared normal 24 hours after treatment.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The study does not need to be conducted because the substance does not meet the criteria for classification as acute toxicity or STOT SE by the oral route and no systemic effects have been observed in in vivo studies with dermal exposure (e.g. skin irritation, skin sensitisation):
- Executive summary:
The study does not need to be conducted because the substance does not meet the criteria for classification as acute toxicity or STOT SE by the oral route and no systemic effects have been observed in in vivo studies with dermal exposure (e.g. skin irritation, skin sensitisation):
The acute oral median lethal dose (LD50) of the test material in the Sprague-Dawley strain rat was found to be greater than 2000 mg/kg bodyweight.
There were no deaths.
No signs of systemic toxicity were noted during the study.
All animals showed expected gain in bodyweight during the study.
No abnormalities were noted at necropsy.The test material when applied as a 20% aqueous dilution produced a primary irritation index of 0.0 and was classified as a NON-IRRITANT to rabbit skin according to the Draize cl assification scheme. No corrosive effects were noted.
No corneal or iridial effects were noted during the study.
Minimal conjunctiva 1 irritation was noted in one treated eye one hour after treatment.
All treated eyes appeared normal 24 hours after treatment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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