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EC number: 284-511-6 | CAS number: 84929-27-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Vitis vinifera, Vitaceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Grape, red, ext.
- EC Number:
- 284-511-6
- EC Name:
- Grape, red, ext.
- Cas Number:
- 84929-27-1
- IUPAC Name:
- 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol; 5-[(2R,3R)-6-hydroxy-2-(4-hydroxyphenyl)-4-[(1E)-2-(4-hydroxyphenyl)ethenyl]-2,3-dihydro-1-benzofuran-3-yl]benzene-1,3-diol
- Test material form:
- solid
Constituent 1
Test organisms
- Test organisms (species):
- Daphnia magna
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 2.1 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 2.1 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 g/L
- Nominal / measured:
- nominal
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 1 g/L
- Nominal / measured:
- nominal
Applicant's summary and conclusion
- Conclusions:
- One valid experiment was performed.
The study was performed using 1 concentration at 1 g/L. For the test concentration and
the blank control, 20 daphnia were exposed to the test item for 48 hours in a static test
system. After 24 and 48 hours, the immobilised daphnia were counted.
None of the animals was immobilised in the blank control as well as in the tested concentration.
Potassium dichromate K2Cr2O7 (CAS No. 7778-50-9) was used as positive control in a
current reference study to assure that the test conditions are reliable.
At the start and at the end of the test, the content of the test item in the test solutions was
determined using measurement of dissolved organic carbon (DOC). Because of the poor
solubility of the test item the correlation between nominal and measured concentration was
weak. However, the measured DOC concentration at the beginning shows that test substance
was present in the test solution. Nevertheless, a much lower concentration was
measured at the end of the test which might have been caused by the presence of the test
organism and adsorption or ingestion of test item onto the daphnia.
The measured concentration based on DOC measurement was 6.3 mg/L at the beginning
of the test and 0.7 mg/L at the end of the test. Therefore, the determination of the results
was based on the nominal concentrations since the correlation between nominal and
measured concentration was very weak and the geometric mean of the measured concentrations
was given as well.
No observations were made which might cause doubts concerning the validity of the study
outcome. All validity criteria were met.
The result of the test is considered valid. - Executive summary:
One valid experiment was performed.
The study was performed using 1 concentration at 1 g/L. For the test concentration and
the blank control, 20 daphnia were exposed to the test item for 48 hours in a static test
system. After 24 and 48 hours, the immobilised daphnia were counted.
None of the animals was immobilised in the blank control as well as in the tested concentration.
Potassium dichromate K2Cr2O7 (CAS No. 7778-50-9) was used as positive control in a
current reference study to assure that the test conditions are reliable.
At the start and at the end of the test, the content of the test item in the test solutions was
determined using measurement of dissolved organic carbon (DOC). The measured concentration
based on DOC measurement was 6.3 mg/L at the beginning of the test and 0.7
mg/L at the end of the test. Therefore, the determination of the results was based on the
nominal concentrations.
Because of the poor solubility of the test item the correlation between nominal and measured
concentration was weak. However, the measured DOC concentration at the beginning
shows that test substance was present in the test solution. Nevertheless, a much
lower concentration was measured at the end of the test which might have been caused
by the presence of the test organism and adsorption or ingestion of test item onto the
daphnia.
Therefore, the biological results were based on the geometric mean of the measured concentrations
and additionally on the nominal concentration.
The following results were determined for the test item Palmitoyl grapevine shoot extract
(species: Daphnia magna).
Geometric mean of measured concentration:
48h-NOEC ≥ 2.1 mg/L
48h-LOEC > 2.1 mg/L
Nominal concentration:
48h-NOEC ≥ 1 g/L
48h-LOEC > 1 g/L
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