Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 701-328-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The key study was conducted to evaluate the potential of the test article to induce hypersensitivity in guinea pigs using the Maximization test (Research & Consulting Company AG, 1990).
For the intradermal induction phase of the study, the test article was diluted to 5% with oleum arachidis. One week later, the epidermal induction started. The test and control group were challenged two weeks after the epidermal induction application. A second challenge was performed two weeks after the first challenge. The challenge site was evaluated 24 and 48 hours after removal of the patch.
The test result of the first challenge in test group showed positive erythema reactions at 24 h and 48 h when treated with 25% test article in vaseline. The test result of the second challenge in test group showed positive erythema reactions at 24 h and 48 h when treated with 25% test article dilution in oleum arachidis.
Therefore, it can be concluded that test article can be classified as a sensitizer (category 1) to the skin of rabbit in accordance with CLP (Regulation EC No. 1272/2008).
Migrated from Short description of key information:
Experimental results indicated that test substance is a sensitizer to the skin of rabbits.
Justification for selection of skin sensitisation endpoint:
well performed with OECD guideline and GLP principle
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Migrated from Short description of key information:
There are no specific data on respiratory sensitisation.
Justification for selection of respiratory sensitisation endpoint:
Since the most likely route is considered to be via dermal and inhalative exposure is not of concern due to low vapour pressure and the substance is not used in aerosol or spray applications, a DNEL for inhalation route is required and not being proposed.
Justification for classification or non-classification
Based on the present condition, it can be concluded that test article can be classified as a sensitizer (category 1) to the skin of rabbit under CLP (Regulation EC No.1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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