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Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18th July 2019 - 10th August 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes
Radiolabelling:
no
Analytical monitoring:
yes
Details on sampling:
sampling intervalls for the transformation products: 0, 1, 2, 5, 10 minutes
Buffers:
- pH: 4, Type of buffer: citric acid buffer
- pH: 7, Type of buffer: ammonium acetate buffer
- pH: 9, Type of buffer: boric acid buffer
Details on test conditions:
Hydrolysis reactions were conducted at 20°C and 50°C and at three pH values (4, 7, and 9).
Transformation products:
yes
No.:
#1
No.:
#2
Key result
pH:
4
Temp.:
20 °C
Hydrolysis rate constant:
> 0.8 min-1
DT50:
ca. 1 min
St. dev.:
6
Type:
(pseudo-)first order (= half-life)
Key result
pH:
7
Temp.:
20 °C
Hydrolysis rate constant:
> 0.8 min-1
DT50:
ca. 1 min
St. dev.:
9
Type:
(pseudo-)first order (= half-life)
Key result
pH:
9
Temp.:
20 °C
Hydrolysis rate constant:
> 0.8 min-1
DT50:
ca. 1 min
St. dev.:
10
Type:
(pseudo-)first order (= half-life)
Key result
pH:
4
Temp.:
50 °C
Hydrolysis rate constant:
> 0.8 min-1
DT50:
ca. 1 min
St. dev.:
6
Type:
(pseudo-)first order (= half-life)
Key result
pH:
7
Temp.:
50 °C
Hydrolysis rate constant:
> 0.8 min-1
DT50:
ca. 1 min
St. dev.:
9
Type:
(pseudo-)first order (= half-life)
Key result
pH:
9
Temp.:
50 °C
Hydrolysis rate constant:
> 0.8 min-1
DT50:
ca. 1 min
St. dev.:
10
Type:
(pseudo-)first order (= half-life)
Details on results:
In all experiments the hydrolysis of the test substance in buffer solutions (pH4, pH7, pH9) takes place immediately. Hydrolysis rates of >= 99% within 1 minute reaction time are observed for all samples.
Validity criteria fulfilled:
yes
Conclusions:
The test substance is hydrolysable at a very high rate (within seconds to minutes) largely irrespective of environmental conditions (relevant temperatures and pH values).

Description of key information

The half-life of the magnesium diethyl dicarbonate was determined to be T1/2 < 1 min (Hydrolysis as a Function of pH). In all experiments the hydrolysis of magnesium diethyl dicarbonate in buffer solutions (pH4, pH7, pH9) could be observed immediately. Hydrolysis rates of >= 99% within 1 minute reaction time are observed for all samples. Magnesium diethyl dicarbonate hydrolyses very rapidly via magnesium ethanolate into carbon dioxide, ethanol and magnesium hydroxide. The hydrolysis product ethanol is readily biodegradable and the hydrolysis product magnesium hydroxide does not contain any hydrolysable functional groups.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 min
at the temperature of:
20 °C

Additional information

Magnesium diethy dicarbonate is an extremely strong conjugate base. In contact with water magnesium diethyl dicarbonate reacts to form carbon dioxide, magnesium hydroxide and ethanol:

(C3H5O3)2Mg + 2 H2O → 2 C2H5OH + Mg(OH)2 + 2 CO2