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Diss Factsheets
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EC number: 701-326-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 20 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 2 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 10 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 10.572 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 1.057 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 2 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 53.33 mg/kg food
- Assessment factor:
- 300
Additional information
Environmental fate and pathways:
The substance is considered to be readily biodegradable (OECD Guideline 301F) and contains organic functional groups that are relatively or completely inert with respect of hydrolysis. The average bioconcentration factor (BCF) of the registered substance determined at 373 L/kg indicates that the substance did not bioaccumulate in the rainbow trout (in vivo OECD Guideline 305 and in vitro biotransformation assays). Finally, the adsorption coefficient (log Koc) of the substance was determined to be 3.72 (OECD Guideline 121). This result indicates that the substance is immobile in soil(according to McCall et al., 1980).
Aquatic toxicity:
No toxic effects were observed up to the attainable limit of solubility of the substance in experimental acute studies for the three trophic levels (fish, aquatic invertebrates and algae).
Regarding long-term exposure, no toxic effect was observed in the algae experimental study at the maximum attainable mean test concentration and in an experimental chronic Daphnia study ( NOACK, 2021) the LOEC value for aquatic invertebrates, based on reproduction, was determined to be > 0.937 mg/L. The value predited by calculation method (KREATiS, 2021) 21d - EL10 = 0.2 mg/L supports this value.
In addition, reliable calculation method result is available to assess chronic toxicity to fish 32d- EL10 value predicted was 0.4 mg/L.
Based on the respiration inhibition test, the substance had no inhibitory effect on the respiration rate of activated sludge, after the incubation period of 3 hours at the maximum test item concentration tested of 100 mg/L.
Terrestrial toxicity:
Effects of registered substance on mortality, biomass and the reproductive potential of the earthworm species Eisenia fetida (Annelida, Lumbricidae) were determined according to OECD 222 (2016) with GLP compliance . Under the test conditions, the NOEC was determined to be at least the nominal concentration 200 mg test item/kg SDW and EC10 at 92.2 mg test item/kg SDW.
Conclusion on classification
No harmonised classification is available.
Data available:
- readily biodegradable;
- average BCF value of 373 L/kg (in vivo OECD Guideline 305 and in vitro biotransformation assay using liver S9 fractions and hepatocytes from rainbow trout)
- acute data: no acute toxic effects were observed on all trophic levels at or even close to the water solubility of the substance;
- chronic data: LOEC > 0.937 mg/L for Daphnia. Supportive chronic data were predicted by calculation method on fish and daphnid, with a lowest EC10 value at 0.2 mg/L for daphnid.
Classification according to the Annex I of the Regulation (EC) No 1272/2008 (CLP): The registered substance is classified as Aquatic chronic 3 for the environment based on chronique toxicity data and the ready biodegradability.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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