Registration Dossier
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EC number: 687-893-6 | CAS number: 1150560-54-5
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 17 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- The study was conducted in compliance with the Principles of OECD Guidlines for Testing of Chemicals No. 117 'Partition Coefficient 9n-octanol/water), High performance liquid chromatography (HPLC) Method.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- not specified
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
- EC Number:
- 687-893-6
- Cas Number:
- 1150560-54-5
- Molecular formula:
- C13H9F4IN2O2
- IUPAC Name:
- 1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Purity: 100%
Batch No.: FTIM31803002
Expiration date: Mar 10, 2019 (retest date)
Physical status: off-white powder
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2
- Remarks on result:
- not measured/tested
- Remarks:
- Temp and pH parameters not tested.
- Key result
- Type:
- Pow
- Partition coefficient:
- 100
- Remarks on result:
- not measured/tested
- Remarks:
- Temp and pH parameters not tested
- Details on results:
Reference substances retention time (min):
- Acetanilide: 3.446
- Phenol: 4.138
- Acetophenone: 5.812
- Nitrobenzene: 7.592
- Methyl Benzoate: 8.276
- Ethyl Benzoate: 12.346
Retention time Test item duplicate: 7.182 min, 7.187 min.
Applicant's summary and conclusion
- Conclusions:
- Based on the test results the Pow of Methyl iodouracil was 100.0, and lgPow was 2.00.
- Executive summary:
The partition coefficient (n-octanol/water) of Methyl iodouracil was determined compatible with the principles of OECD guidelines for testing of chemicals no. 117 'partition coefficient (n-octanol/water), high performance liquid chormatography (HPLC) method. Based on the test results the Pow of Methyl iodouracil was 100.0, and lgPow was 2.00.
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