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Diss Factsheets
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EC number: 609-782-3 | CAS number: 400827-68-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Administrative data
First-aid measures
Fire-fighting measures
Accidental release measures
Handling and storage
2.1 Raw Materials Preparation
The correct quantity of raw material to use in the manufacturing process is prepared by weighing it under the local exhaust.
2.2 Charging of Raw Materials in the synthesis reactor
Powders
- Solid raw materials are charged in the reactor through the hatch under the local exhaust.
Liquids
Reactives stored in Drums
Reactives are charged in reactors through a dosing pump from their original container, in which they have already been weighed in the Raw Material preparation department.
Solvents stored in Tanks.
Solvents are contained in tanks and are charged in the reactor through a fixed line equipped with a counter and with a reactor under a vacuum residue condition.
The solvent requests from the tanks are driven by the PLC (Process Logic Control) System, through a remote control. The operator acts on the main control panel. The whole system is closed.
Before the solvent request, the operator enables the receiving reactor to receive the solvent, actioning one or more valves, to allow the operation. The operator then dials on the display the correct type of solvent requested in entrance (the choice is related to the lines entering in the reactor) and the requested quantity.
2.3 Reaction Solution transfer from reactor to reactor.
The whole process takes place in a continuous and closed system. Inside the system a liquid flow is generated caused by a pressure gradient. This pressure gradient is generated by a vacuum system present on the receiving reactor and by generating pressure on the starting reactor.
2.4 In process controls – Sample Analysis
The synthesis reactor has a valve for sample withdrawal.
Sampling is done by authorized personnel wearing adequate protections.
The samples withdrawn are then analysed in laboratory only by qualified personnel.
2.5 Discharge of product from synthesis reactor and packaging
The finish product is discharged automatically, in double lined with polythene bags drums under laminar flow hood.
3. Storage
The product, after been packaged, is stored in a specific area of the warehouse waiting for the QC approval.
4. Intermediate transformation in the next synthesis process.
In the next synthesis process the intermediate enters as a raw material. It is charged in the reactor under the local exhaust and then transformed in another product through a Methylation reaction and the deprotection of the two protective groups: Dimethylphenylester and Phenylacetamido.
5. Description of Control Technical Measures of the Workers Exposure.
The whole process is done in a closed and continuous system, with occasional controlled exposure.
As already mentioned, the charging and discharging operations are performed with the use of the local exhaust. Beside the workers have the individual protection devices and the workplaces are periodically controlled for both the workers exposure to organic volatile substances and to the powder levels.
(TLV-TWA determination).
6. Description of Individual Protection Devices.
For all the operations above mentioned, in paragraphs 2, 3, 4, the workers use suitable individual protection devices. (gloves, protective glasses, masks with suitable filter, overalls).
7. Abatement systems description.
The production plant is connected to a local abatement system.
The local exhausts have dishes scrubber.
The oil vacuum pumps, dryers vacuum pumps, tanks airholes emissions are all conveyed to the cryogenic equipment and active carbons in double layer.
8 Waste Water Treatment, Solid Waste Treatment
Liquids (Waste from Organic Chemical processes)
Organic solvents, washing solutions and waste waters are all disposed as dangerous special waste.
Solids
Containers with residue of dangerous substances inside or contaminated by these substances, for example the individual protection devices or adsorbent materials, are disposed as special dangerous material.
9. Cleaning of the Production Plant
The production plant, at the end of the production, is always subject to a series of washes before re-starting the manufacture of another product.
10 Special Procedure adopted in case of leakages
Any product loss in the synthesis department, as liquids or powders spills, are not to be considered dangerous for the external environment because collecting ducts are present; they collect and convey these substances to the waste water treatment.
In all the areas in which there is a risk of spillage there are present drums containing materials with a high absorbent capacity to soak up any leakage.
11. Workers Training
Only authorized and qualified personnel can enter and work in the Production department and in the Warehouse.
12.Measures of risk management adopted in accordance with the Legislative Decree 81/08
(Security) and DLGS 334/99.
With the entry into force of the above mentioned decree, our company has adapted to the obligation of the update of the documentation related to the company security.
This, with regard to the provisions relevant to risks evaluation, lead to the preparation of the Risks Evaluation Document. In this document, all the risks considered in the above mentioned decree, have been evaluated.
Being the production plant under the “Seveso Law”, the Security management system is active at this site.
13. Measures of risk management adopted in accordance with the Legislative Decree 152/06
(Environment)
Our company acts applying measures of risk management in compliance with the above mentioned decree.
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
Stability and reactivity
Disposal considerations
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.