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EC number: 235-930-8 | CAS number: 13051-49-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 48 hours, February/March 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test performed according to GLP rules and according to OECD guideline 202
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-chloro-3-oxopentyl acetate
- EC Number:
- 235-930-8
- EC Name:
- 2-chloro-3-oxopentyl acetate
- Cas Number:
- 13051-49-5
- Molecular formula:
- C7H11ClO3
- IUPAC Name:
- 2-chloro-3-oxopentyl acetate
- Details on test material:
- - Name of test material (as cited in study report): Chlorketone
- Physical state: liquid
- Lot/batch No.: average sample of 01199815, 01199905, 01200127,01200175
- Stability under test conditions: 8 - 15 months
- Storage condition of test material: keep away from oxidising agents
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Melting point: < -30° C
- Boiling point: 246 °C
- Vapour pressure: 1.3 mbar
- Water solubility (under test conditions): 1.0 mg/l
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- no data
Test solutions
- Vehicle:
- not specified
- Details on test solutions:
- test substance "not difficult"
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name:
- Strain: Strauss, Stamm Berlin
- Age at study initiation (mean and range, SD): 1- 24 h
- Method of breeding: EN IS0 6341
- Feeding during test
- Food type: Tetra AniminB, Scenedesmus subspicafus
ACCLIMATION
- Acclimation period: 24 h
- Acclimation conditions (same as test or not): same
- Type and amount of food: -
- Feeding frequency: -
- Health during acclimation (any mortality observed): no mortality observed
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 24 h
- Post exposure observation period:
- -
Test conditions
- Hardness:
- not recorded
- Test temperature:
- 20+/- 2°C
- pH:
- 7.6 - 8.4
- Dissolved oxygen:
- 8.6 - 9.7
- Salinity:
- potable water contained: Ca2+ 31,6 mg/l, Mg2+ 5,5 mg/l, K+ 3,2 mg/l, Na+ 11,2 mg/l
added: CaCl2*2H20 177,9 mg/l, MgS04*7H20 67,4 mg/l, NaCl 17,8 mg/l - Nominal and measured concentrations:
- 1000 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): open
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates):4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates):
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:
- Total organic carbon:
- Particulate matter:
- Metals:
- Pesticides:
- Chlorine:
- Alkalinity:
- Ca/mg ratio:
- Conductivity:
- Culture medium different from test medium:
- Intervals of water quality measurement:
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod: 16 / 8
- Light intensity:
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
TEST CONCENTRATIONS
- Spacing factor for test concentrations:
- Justification for using less concentrations than requested by guideline:
- Range finding study
- Test concentrations:
- Results used to determine the conditions for the definitive study: - Reference substance (positive control):
- yes
- Remarks:
- K2Cr2O7
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 76 - < 98 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL
- Duration:
- 24 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 68 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- 500 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: not found
- Observations on body length and weight: not recorded
- Other biological observations: not relevant - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- EC50/LC50: 1.82 mg/l - Reported statistics and error estimates:
- 24 h EC50: 85 mg/l (95%: 76 - 98 mg/l)
24 h EC50 (ref): 1.82 mg/l (+- 0.03 mg/l)
Any other information on results incl. tables
no remarks
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 24 h EC 50 value is 85 mg/l (95% confidence limits: 76 - 98 mg/l)
NOEL (24h): 68 mg/l
EC 100 (24h): 500 mg/l - Executive summary:
A range-finding test was followed by a final EC50 test performed under static conditions for 24 hours of exposure. In the final EC50 test Daphnia were exposed for a maximum of 24 hours to 12 different concentrations
The study included a blank-control. The test was performed in quadruplicate with 5 daphnia
per vessel. The 24h EC50 was determined to 85 mg/l (95% range: 76 - 98 mg/l).
24 h EC50 (reference substance) = 1.82 mg/l
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