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Diss Factsheets
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EC number: 701-314-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report equivalent or similar to OECD guideline (402): GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Alkenes, C6-11 (branched), hydroformylation products, distn. residues, heavy cracked fraction
- EC Number:
- 701-314-7
- Molecular formula:
- CnH2n+2O2. n=24-33
- IUPAC Name:
- Alkenes, C6-11 (branched), hydroformylation products, distn. residues, heavy cracked fraction
- Details on test material:
- - Name of test material (as cited in study report): MRD-85-608
- Physical state: yellow liquid
- Analytical purity: assumed 100%
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Research Products, Inc., Denver, PA
- Age at study initiation: approximately 14 weeks
- Weight at study initiation: males (2.26-2.34 kg), female (2.50-2.60 kg)
- Fasting period before study: n/a
- Housing: individually
- Diet (e.g. ad libitum): Purina certified rodent chow, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 15 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-21
- Humidity (%): 40-70
- Air changes (per hr): n/a
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal surface from the shoulder region to the lumbar region
- % coverage: n/a
- Type of wrap if used: occlusive plastic over gauze
REMOVAL OF TEST SUBSTANCE
- Washing (if done): distilled water and paper towels
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 3160 mg/kg (3.63 ml/kg)
- Concentration (if solution): Assumed 100%
- Constant volume or concentration used: yes - Duration of exposure:
- 24 H
- Doses:
- 3160 mg/kg (3.63 ml/kg based on a density of 0.87 g/ml)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 2 and 4 hours after dosing and daily thereafter for 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology - Statistics:
- The means and standard deviations of the body weights and body weight changes were calculated.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Remarks on result:
- other: No deaths observed
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3.63 mL/kg bw
- Remarks on result:
- other: No deaths observed
- Mortality:
- No deaths observed.
- Clinical signs:
- other: Dermal exposure elicited well-defined to moderate-severe erythema in all animals at the 24 hour observation period. As the study progressed, these observations subsided. Nasal discharge, food comsumption decrease, staining in the ano-genital area, unthr
- Gross pathology:
- I animal had maloccluded incisors and 3 animals had alopecia. Three of the 6 test animals exhibited no observable abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 for the registered substance is greater than 3160 mg/kg.
- Executive summary:
The acute dermal irritation potential and systemic toxicity of the registered substance were evaluated in 6 male and female rabbits via the occluded patch method. A dose of 3160 mg/kg (3.63 ml/kg) was applied to the clipped backs of the rabbits for 24 hours. Following patch removal, observations occurred daily for 14 days to assess irritation and systemic toxicity. There were no animal deaths during the course of the study. The acute dermal LD50 for the registered substance is greater than 3160 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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