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EC number: 605-140-1 | CAS number: 158237-07-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb 22 1995 - May 6 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- 2.5 mg/L
- Temp.:
- 20 °C
- Remarks on result:
- other: unbuffered solution
- Water solubility:
- 2.3 mg/L
- Temp.:
- 20 °C
- pH:
- >= 4 - <= 9
Reference
Preliminary test
In a preliminary test the water solubility was determined to be approx. 4 mg/L (Bayer AG, Nov. 11, 1993).
Summary of results
| acidic | neutral | pH 5.5 - 7 | alkaline | ||||
| phosphate buffer c(NaH2P04 x 2H2O) = 0.01 Mole/L adjusted to pH 4 with cone. H3PO4 | phosphate buffer c(Na2HPO4 x 12H2O) = 0.01 Mole/L adjusted to pH 7 with cone. H3PO4 | unbuffered water in equilibrium with atmospheric carbon dioxide | boratebuffer c(Na2B4O7 x 10H2O) = 0.01 Mole/L | ||||
pH | 4 | 7 | 5 | 9 | ||||
| concentration | concentration | concentration | concentration | ||||
| [mg/ L ] | [mg/ L ] | [mg/ L ] | [mg/ L ] | ||||
eluation column flow rate (mL/min) | 0.6 | 1.1 | 0.6 | 1.0 | 0.8 | 1.0 | 0.8 | 1.6 |
| 2.28 | 2.44 | 2.30 | 2.36 | 2.57 | 2.52 | 2.29 | 2.33 |
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mean | 2.36 | 2.33 | 2.54 | 2.31 | ||||
rel. standard deviation | 4.79 % | 1.82% | 1.39% | 1 .22 % |
The means from the results of 2 concentration measurements performed for each pH range are summarized in the table given above. It becomes evident that there is no significant dependence on the flow-rate showing that the solubility equilibrium was reached in all cases. By comparing the results from different series and considering the scope of the analytical error it becomes evident that there is no influence of the pH on the solubility between pH 4 and 9. However, there seems to be a slight influence of the salinity of solutions giving rise to higher concentrations measured for pure water.
The water solubility of the test substance is 2.5 mg/L in unbufferd aqueious solutions and 2.3 mg/L in buffered aqueous solutions in the range between pH 4 and pH 9 at 20 °C. The solubility is not influenced by the pH in the range between pH 4 and pH 9. The lower results for buffered solutions shows an influence of salinity on the solubility.
Description of key information
Water solubility: 2.5 mg/L at 20 °C [pure water]; 2.3 mg/L at 20 °C [buffer solution, pH 4-9] (OECD Guideline 105, column elution method)
Key value for chemical safety assessment
- Water solubility:
- 2.5 mg/L
- at the temperature of:
- 20 °C
Additional information
Solubility in pure water is selected as key value for CSA. The solubility is not influenced by the pH in the range between pH 4 and pH 9. The lower results for buffered solutions shows an influence of salinity on the solubility.
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