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EC number: 465-070-0 | CAS number: 518048-03-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 465-070-0
- EC Name:
- -
- Cas Number:
- 518048-03-8
- Molecular formula:
- C16H19FN403
- IUPAC Name:
- 2-(2-aminopropan-2-yl)-N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide
- Details on test material:
- Free Amine Batch Code # 200601180120.
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, industrial, adapted
- Details on inoculum:
- The activated sludge was collected from the aeration tank of a civil wastewater treatment plant, washed by centrifugation, the supemalant liquid decanted and the solid material re-suspended in tap water. The washing procedure was repeated three times. A homogenized aliquot of the final sludge suspension has been weighted, dried, and the ratio of wet to dry weight was calculated.
Before using it, the sludge was diluted with test water to a concentration of 15 mg/L (dry weight basis). - Duration of test (contact time):
- 11 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- other: nominal concentrations
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- The assay on test item has been run in parallel with a ready biodegradable reference substance (Sodium Benzoate), the inoculum control, the abiotic control containing the test item and a sterilizing agent (HgCl2), and the toxicity control containing test item, reference compound and inoculum.
BOD flasks of 500 ml capacity, equipped with pressure sensors fitted on the bottle mouth, have been used as test units.
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Test performance:
- Conditions for the validity of the test :
- the oxygen demand of the inoculum control is normally 20-30 mgO2/L and should not be greater than 60 mgO2/L within 28 days.
- the degradation rates of the two test flasks containing the test item, test water and inoculum should not deviate by more than 20% at the time the plateau is reached, at the end of the test or at the end of the 10-day window
- the percentage degradation of the reference item must reach the pass level for ready biodegradation ( at least 60% of ThOD) within the 10-days window (ThOD = Theorical Oxygen demand)
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 1 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- -1.3
- Sampling time:
- 2 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2.9
- Sampling time:
- 3 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 3.2
- Sampling time:
- 4 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2.2
- Sampling time:
- 5 d
- Details on results:
- %Degradation : 3.8 at 6 d
%Degradation : 2.9 at 7 d
%Degradation : 4.5 at 8 d
%Degradation : 5.1 at 11 d
BOD5 / COD results
- Results with reference substance:
- Day # - % Degradation
1 - 30
2 - 43.8
3 - 61.2
4 - 69.0
5 - 78.6
6 - 87.6
7 - 97.2
8 - 106.2
11 - 121.8
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not inherently biodegradable
- Conclusions:
- The test item Free Amine has shown to be not ready biodegradable under the conditions applied in a Manometric Respirometry test, having not reached the pass level (60% biodegradation) but showing a percentage degradation around of 5% at the end of the 10-day window.
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