Registration Dossier
Registration Dossier
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EC number: 206-585-0 | CAS number: 355-42-0
Endpoint summary
Administrative data
Description of key information
Tetradecafluorohexane is a highly insoluble substance.
Indeed, in a water solubility assay in which no precise value was possible to obtain, an overall solubility in water < 100 µg/ L was concluded and a solubility <20 µg/L was oberved after more than 24h.
Moreover, the solubility assay was performed in closed vessel to minimize volatization, with continuous stirring, and the concentrations measured were probably far higher than what could be expected to be reached in the environment or in a long term toxicity assay on fish or daphnia.
Therefore, short-term toxicity to aquatic invertebrates was considered irrelevant, and corresponding endpoints were waived according to Reach annexes VII and VIII dispositions.
Long-term toxicities assays were therefore considered.
QSAR prediction was performed for long-term toxicity to fish and aquatic invertebrates.
NOEC predicted for long-term toxicity in fish and aquatic invertebrates are above the limit of solubility of tetradecafluorohexane observed in a water solubility assay:
-The 28d NOEC in fish predicted by QSAR calculation, on the basis of a water solubility predicted to be 7.02 mg/L, was 0.11 mg/L
-The 21d NOEC in daphnia predicted by QSAR calculation, on the basis of a water solubility predicted to be 7.02 mg/L, was 0.072 mg/L.
In a water solubility assay performed otherwise, poor water solubility combined with high volatility made impossible to solubilize tetradecafluorohexane at higher concentration than 0.02 mg/L after more than 24 hours. Moreover, the solubility assay was performed in closed vessel to minimize volatization, with continuous stirring, and the concentrations measured were probably far higher than what could be expected in the environment or in a long term toxicity assay on daphnia.
Therefore, it can reasonably be concluded that the 21d NOEC predicted is above the limit of solubility of tetradecafluorohexane.
QSAR prediction was performed for toxicity to microorganisms in activated sludges.
No toxicity is anticipated in the limit of solubility further to a
30-180 minute study on activated sludge based on measured concentrations.
Additional information
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