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Diss Factsheets
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EC number: 700-697-8 | CAS number: 264145-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 March to 12 May 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study undertaken at a GLP accredited laboratory, to internationally accepted guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 437 (The Bovine Corneal Opacity & Permeability Assay (BCOP))
- Deviations:
- yes
- Remarks:
- The description of the substance was amended to light yellowish green powder as required by the Sponsor.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- LumiNova Blue Green
- IUPAC Name:
- LumiNova Blue Green
- Details on test material:
- - Name of test material (as cited in study report): LumiNova Blue Green
- Substance type: Phosphorescent pigment
- Physical state: Light yellowish green powder
- Analytical purity: > 99%
- Lot/batch No.: PBM-029
- Expiration date of the lot/batch: 04 February 2012
- Storage condition of test material: Room temperature in the dark
Constituent 1
Test animals / tissue source
- Species:
- other: isolated bovine corneas
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- Not applicable as the assay uses isolated bovine corneas as a means of assessing the ocular corrosivity or severe irritancy potential of test substances in vitro. The isolated corneas were obtained as a by-product of the meat production industry.
Test system
- Vehicle:
- other: 0.9% sodium chloride solution
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 750 µl
- Concentration (if solution): 0.9% NaCl solution
CONTROLS (positive and negative)
- Amount(s) applied: 750 µl
- Concentration (if solution): 0.9% NaCl solution
VEHICLE
- Amount applied: 750 µl
- Concentration (if solution): 0.9% - Duration of treatment / exposure:
- 4 hours ± 5 minutes
- Observation period (in vivo):
- None
- Number of animals or in vitro replicates:
- Not applicable
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 4 hours ± 5 minutes
SCORING SYSTEM: In Vitro Irritancy Score = Corrected Opacity Value + (15 x Corrected OD490 Value)
TOOL USED TO ASSESS SCORE: Minimal Essential Medium (cMEM)
Results and discussion
In vivo
Results
- Irritation parameter:
- other: In Vitro Irritancy score
- Basis:
- other: In Vitro Irritancy Score = Corrected Opacity Value + (15 x Corrected OD490 Value)
- Time point:
- other: Not applicable
- Score:
- 5.3
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Data for maximum score not applicable for BCOP study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information The IVIS score from the swabbed corneas in assay 3 was considered to be the conclusive result. Criteria used for interpretation of results: OECD GHS
- Conclusions:
- In assay 3, the IVIS for the corneas washed using the usual procedure was greater than that for the swabbed corneas. The results for assay 3 show that adherence of the test material to the corneas greatly increased the IVIS and thereby gave an artifactual result. The IVIS score from the swabbed corneas in assay 3 was considered to be the conclusive result. The test substance, LumiNova Blue Green, elicited an In Vitro Irritancy Score of 5.3 ± 1.0. This value was substantially below the classification threshold of 55.1 and therefore LumiNova Blue Green was predicted to be a non-corrosive/non-severe eye irritant.
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