Propylene dinonanoate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

No purity of test substance reported.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not applicable

Principles of method if other than guideline:

Study was conducted prior to adoption of any OECD guideline.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propylene dinonanoate

EC Number:

255-350-9

EC Name:

Propylene dinonanoate

Cas Number:

41395-83-9

Molecular formula:

C21H40O4

IUPAC Name:

propylene dinonanoate

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Fasting period before study: yes, 20-24 h
- Housing: 2-5 per cage

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

The test material was administered as supplied by the sponsor.

Doses:

Preliminary test: 1000, 5000, 10000 mg/kg bw
Main test: 10000, 15000, 20000 mg/kg bw

No. of animals per sex per dose:

Preliminary test: 2 at 1000 mg/kg bw, 1 at 5000 and 1 at 10000 mg/kg bw
Main test: 5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

Statistics:

Probit method

Results and discussion

Preliminary study:

2m+2f animals at 1000 mg/kg: no mortality
1m+1f animal at 5000 mg/kg: no mortality
1m+1f animal at 10000 mg/kg: no mortality

Effect levels

Effect levels 1

Key result

Sex:

male/female

Dose descriptor:

LD50

Remarks:

rat

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

male/female

Dose descriptor:

LD50

Remarks:

rat

Effect level:

16 025 mg/kg bw

Based on:

test mat.

Remarks:

Calculated using Probit method

95% CL:

> 12 973 - < 19 795

Remarks on result:

other:

Remarks:

5 out of 10 animals were dead after 14d observation period after single oral dosing at 15000 mg/kg

Mortality:

1 out of 10 rats was found dead after dosing at 10000 mg/kg. No mortality was seen in the preliminary study.

Any other information on results incl. tables

Dose mg/kg	Gender	Total number of rats	Number of dead rats after 14 day observation period	% mortality
1000	m	2	0	0
1000	f	2	0	0
5000	m	1	0	0
5000	f	1	0	0
10000	m	1	0	0
10000	f	1	0	0
10000	m	5	1	10
10000	f	5	0	0
15000	m	5	4	80
15000	f	5	1	20
20000	m	5	4	80
20000	f	4	2	50

Applicant's summary and conclusion

Interpretation of results:

other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008.