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Diss Factsheets

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-05-07 - 2018-06-25
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
no
Type of method:
gas saturation method

Test material

Constituent 1
Chemical structure
Reference substance name:
1-benzyl-5-phenylbarbituric acid
EC Number:
276-940-2
EC Name:
1-benzyl-5-phenylbarbituric acid
Cas Number:
72846-00-5
Molecular formula:
C17H14N2O3
IUPAC Name:
1-benzyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
Molecular Formula : C17H14N2O3
Molecular Weight : 294.3
Physical Appearance : White powder
CAS No. : 72846-00-5
Batch Number : 170240
Purity : 99.5%

Results and discussion

Vapour pressureopen allclose all
Key result
Test no.:
#2
Temp.:
120 °C
Vapour pressure:
0.003 Pa
Key result
Test no.:
#3
Temp.:
130 °C
Vapour pressure:
0.097 Pa
Key result
Test no.:
#4
Temp.:
140 °C
Vapour pressure:
0.021 Pa
Key result
Test no.:
#1
Temp.:
25 °C
Vapour pressure:
0 Pa

Applicant's summary and conclusion

Conclusions:
Based on the results obtained from the study, it is concluded that, the vapour pressure of
1-Benzyl-5-phenylbarbituric acid (BPBA) is 2.20 x 10-7Pa at 25 degree C.
Executive summary:

The study entitled “Determination of Vapour Pressure of 1-Benzyl-5-phenylbarbituric acid (BPBA) ”

was performed in compliance with Study Plan No. P/PCP2654/VP/18 which incorporated the

recommendations made in the Guidelines: OECD 104, OPPTS 830.7950 and EEC A.4.

The vapour pressure of test item was determined using "gas saturation method". The test item was

loaded into a 5 mm inner diameter stainless steel trap, between glass wool plugs. The trap was filled

with silica gel in two equal portions using glass wool plugs. The stainless steel trap containing test

item and silica gel trap were arranged in series and kept in oven to attain test temperature. Inert gas

(Nitrogen) was passed slowly, at selected temperatures of 120, 130 and 140 ºC and at set flow rates

of 50, 100 and 150 mL/minute through the test item, to ensure saturation. The set up was left for

saturation at test temperature for 48 hours. The transported test item was trapped using sorbent

(Silica traps). After the specified duration (48 hours), the traps were taken out and amount of test item

trapped in the two layers of the silica was analyzed by HPLC method. The two layers of silica gel

separated from traps were extracted for determination of amount of test item trapped in them. The

vapour pressure was calculated from the known total gas volume and the weight of material

transported.

Based on the results obtained from the study, it is concluded that the vapour pressure of

1-Benzyl-5-phenylbarbituric acid (BPBA) is 2.20 x 10-7 at 25 ºC.