Registration Dossier
Registration Dossier
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EC number: 222-884-9 | CAS number: 3648-20-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- The study predates GLP and the description of method is not provided.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the Toxicity of Phthalates via Ingestion
- Author:
- Krauskopf L G
- Year:
- 1 973
- Bibliographic source:
- Environmental Health Perspectives 3:61-72.
Materials and methods
- Principles of method if other than guideline:
- - Principle of test:
Rats given single doses of DUP of up to at least 15.8 g/kg bw.
- Short description of test conditions: No data on test method.
- Parameters analysed / observed: Animals observed for signs of toxicity. - GLP compliance:
- no
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Diundecyl phthalate
- EC Number:
- 222-884-9
- EC Name:
- Diundecyl phthalate
- Cas Number:
- 3648-20-2
- Molecular formula:
- C30H50O4
- IUPAC Name:
- 1,2-diundecyl benzene-1,2-dicarboxylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- up to at least 15.8 g/kg bw
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 15 800 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- other: No significant toxic effects
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified (CLP Regulation EC no. 1272/2008)
- Conclusions:
- The acute oral LD50 value of the test substance is higher than 15.8 g/kg bw in rats.
- Executive summary:
A single dose toxicity study was conducted with DUP in rats up to at least 15.8 g/kg bw. No mortalities were reported. Under the conditions of this study DUP was considered practically non-toxic. Thus, it can be concluded that the acute oral LD50 value of the test substance is higher than 15.8 g/kg bw in rats.
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