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EC number: 227-743-5 | CAS number: 5964-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Treatment of the intact rabbit skin with an 80% aqueous preparation of Na4 EDTA resulted in mild or no irritation. These data demonstrate that there is no need to classify and label the substance for skin irritating properties according to EU or GHS regulations. However, irreversible opacity is caused by instillation of undilluted test substance into the eye of rabbits. Therefore, undiluted Na4EDTA has to be labeled according to EU and GHS regulations.
Based on the read across on EDTA 4Na, it is expected that EDTA 4K may have the same effects.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
In the key study which was performed according to OECD guideline 404 the skins of 2 male and 1 female rabbits were exposed to 0.5 g of an 80% aqueous preparation of Trilon B Powder (edetic acid tetrasodium salt, 80% aqueous preparation) for an occlusive exposure period of 4 hours. For erythema medium scores after 24/48/72 hours of 1/0/0.3 were documented, redness had resolved after 8 days. No edema was noted (BASF, 1982).
After treatment of skin of 2 rabbits with Trilon B liquid (40% aqueous solution of edetic acid tetrasodium salt) for 1, 5, 15 minutes and 20 hours on the back and for 20 hours on the ear skin readings were performed 24 and 48 h after removal of the test substance. A mild redness (score 0.5) on back and ear of one rabbit after a 20-hour exposure period. Those effects were fully reversible within 48 h. After exposure periods of 15 minutes or less no effects were observed (BASF, 1978).
Eye irritation:
Approximately 50 mg of the test substance were applied to the conjunctival sac of one eye of 2 animals. 24 to 72 h after application a mild redness (score 1), mild edema (scale 0.8) and mild opacity (scale 1.3) was present and after 8 days mild redness and mild oedema and mild opacity persisted. During all these observation times a grease-like layer was observed
(BASF, 1978)
Instillation of 50 mg of of the substance to
the eye of one rabbit resulted redness (score 1.75), oedema (score 1.25)
and opacity (score 1.3) and pus formation as average 24 -72 h after
application. After 8 days a mild opacity was seen (BASF, 1970).
Effects on eye irritation: corrosive
Justification for classification or non-classification
Based on the results obtained in the toxicity studies and taking into account the provisions laid down in Council Directive 67/548/EEC and CLP, a classification as Xi, R41 and Eye Damage Cat 1, respectively, has to be done with respect to irritation or corrosion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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