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EC number: 272-782-3 | CAS number: 68911-68-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 June 1971 to 09 September 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. Federal Hazardous Substances Act
- Version / remarks:
- September 17, 1964
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Amines, C12-14-tert-alkyl, compds. with 2(3H)-benzothiazolethione
- EC Number:
- 272-782-3
- EC Name:
- Amines, C12-14-tert-alkyl, compds. with 2(3H)-benzothiazolethione
- Cas Number:
- 68911-68-2
- Molecular formula:
- N/A
- IUPAC Name:
- C12-14-tert-alkylamines, compds. with 2(3H)-benzothiazolethione
- Test material form:
- liquid
1
- Specific details on test material used for the study:
- - Description: Viscous, amber liquid with an unpleasant odor
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Remarks:
- Albino
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 1 μL
- Observation period (in vivo):
- 24, 48 and 72 hours following application
- Details on study design:
- J. H. Draize, “Dermal Toxicity,” in Appraisal od the Safety of Chemicals in Foods, Drugs and Cosmetics, The Staff of the Division of Pharmacology of the Federal and Drug Administration (Austin, Texas: The Editorial Committee of the Association of Food and Drug Officials of the United States, 1959), p. 51.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- > 16 - < 83
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 72 hrs
- Remarks on result:
- positive indication of irritation
Any other information on results incl. tables
Irritative effects included moderate or marked corneal opacity and conjunctivitis and mild iritis in each animal. Onset of these irritative effects was within 24 hours following application and they were relatively unchanged in five animals throughout the study. Irritative effects subsided significantly in the sixth animal. Four animals exhibited bleeding of the conjunctivae at the 24- and/or 48-hour observations.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Application of the test material to the eyes of albino rabbits produced corneal opacity, conjunctivitis, iritis, and conjunctival bleeding.
- Executive summary:
In a study conducted according to the U.S. Federal Hazardous Substances Act, the test material when applied undiluted to the eyes of albino rabbits produced corneal opacity, conjunctivitis, iritis, and conjunctival bleeding. The test material is classified as a Category 1 according to GHS.
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