2,4-dihydroxybenzoic acid

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12.02.2018 - 12.02.2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Version / remarks:

1981

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Version / remarks:

2009

Deviations:

no

GLP compliance:

no

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

2,4-dihydroxybenzoic acid

EC Number:

201-946-9

EC Name:

2,4-dihydroxybenzoic acid

Cas Number:

89-86-1

Molecular formula:

C7H6O4

IUPAC Name:

2,4-dihydroxybenzoic acid

Test material form:

solid

Results and discussion

Mass median aerodynamic diameter:

12 µm

Geometric standard deviation:

3

Particle size

Particle size 1

Key result

Percentile:

D10

Mean:

1.6 µm

St. dev.:

0.01

Particle size 2

Key result

Percentile:

D50

Mean:

10.1 µm

St. dev.:

0.05

Particle size 3

Key result

Percentile:

D90

Mean:

34 µm

St. dev.:

0.13

Any other information on results incl. tables

Two test series of 3 measurements each were performed with the test item.

 Test series 1:

D₁₀:      1.6 µm                                                         Standard deviation: 0.01 µm

D₅₀:      10.2 µm         (Median diameter)                Standard deviation: 0.05 µm

D₉₀:      33.8 µm                                                        Standard deviation: 0.18 µm

Test series 2:

D₁₀:      1.6 µm                                                        Standard deviation: 0.01 µm

D₅₀:      10.1 µm         (Median diameter)                Standard deviation: 0.15 µm

D₉₀:      34.1 µm                                                        Standard deviation: 0.23 µm

Average

D₁₀:      1.6 µm                                                         Standard deviation: 0.01 µm

D₅₀:      10.1 µm         (Median diameter)                Standard deviation: 0.05 µm

D₉₀:      34.0 µm                                                        Standard deviation: 0.13 µm

Applicant's summary and conclusion

Conclusions:

2,4-Dihydroxybenzoic acid has a median particle size of D50 = 36 µm.

Executive summary:

The test item 2,4-Dihydroxybenzoic acid has a median particle size of D50 = 10 µm and a MMAD of 12 µm with a GSD of 3.0, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981) and ISO 13320 (2009).