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Diss Factsheets
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EC number: 947-711-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2001-02-07 to 2001-03-15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- Commission Directive 92/69/EEC (0.J. No. L383A, 29.12.92) Part C, Method 2 'Acute toxicity
for Daphnia' - Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Remarks:
- TOC determination
- Details on sampling:
- - Sampling:
Control - at 0 and 48 hours
Test concentration - at 0 and 24 hours - Vehicle:
- no
- Details on test solutions:
- To prepare the test item solutions the following masses were added to 1 L each of dilution water: 1.3, 2.5, 5.3 and 10.6 mg. Each solution was treated with ultra turrax for 60 seconds and then stirred for 24 hours on a magnetic stirrer. The undissolved particles particle of the test solution were removed by filtration. Considering the heterogeneous composition of the test item, Water Accomodation Fractions (WAF) were tested.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain/clone: STRAUS
- Food type: unicellular green algae (Scenedesmus subspicatus CHODAT)
- Amount: 'ad libitum' - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 14.7 °dH (= 262.4 mg/L CaCO3)
- Test temperature:
- 18 - 22 °C
- pH:
- 7.8 - 7.9
- Dissolved oxygen:
- 7.7 - 8.8 mg/L
- Nominal and measured concentrations:
- Nominal concentrations: 1.25, 2.5, 5 and 10 mg/L
No measured concentrations. - Details on test conditions:
- TEST SYSTEM
- Test vessel:50 mL glass beaker
- Fill volume: 20 mL test medium
- Aeration: none
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Feeding during the test: none
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: M4 medium
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: none
- Photoperiod: 16 h light : 8 h dark
- Light intensity: < 1000 lux - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- EL0
- Effect conc.:
- 2.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EL0
- Effect conc.:
- 1.25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EL50
- Effect conc.:
- 3.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- 2.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Geometric mean of EL0 and EL100
- Duration:
- 24 h
- Dose descriptor:
- EL100
- Effect conc.:
- 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EL100
- Effect conc.:
- 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Highest test concentration resulting in 0 % immobilisation (EL0 48h): 1.25 mg/L
Lowest test concentration resulting in 100 % immobilisation (EL100 48h): 5 mg/L
Results were expressed in terms of effective loading (EL) at 24 and 48 h. - Validity criteria fulfilled:
- yes
- Conclusions:
- The EL50 of the test item on the mobility of Daphnia magna was determined to be 2.5 mg/L at 48 h exposure (gepmetric mean of EL0 and EL100).
- Executive summary:
In the acute immobilisation test with Daphnia magna (STRAUS), the effects of the test item were determined according to Commission Directive 92/69/EEC (0.J. No. L383A, 29.12.92) Part C, Method 2 'Acute toxicity for Daphnia' and OECD 202. The study was conducted in a static system over a period of 48 hours with nominal concentrations prepared with WAF - 1.25, 2.5, 5 and 10 mg/L. 20 daphnids per test concentration and control were tested in two replicates. The total organic carbon (TOC) of the test item was determined with TOC Analyzer. The biological endpoints were based on the nominal concentration.There was no immobilisation observed in twenty daphnids exposed to the test item concentration of 1.25 mg/L. A 100 % immobility was observed at two highest concentrations 5 and 10 mg/L tested. The estimated EL50 value (48 hours) of the test item based on the nominal concentration is 2.5 mg/L (geometric mean of EL0 and EL100).
Reference
Table 1. Summarised results of immobilisation of the tested individuals (20 individuals per concentration/control)
Time of observations (h) |
Cummulative immobilisation (immobile individuals / %) |
||||
Control |
1.25 mg/L |
2.5 mg/L |
5 mg/L |
10 mg/L |
|
24 |
0 / 0 |
0 / 0 |
0 / 0 |
20 / 100 |
20 / 100 |
48 |
0 / 0 |
0 / 0 |
8 / 40 |
20 / 100 |
20 / 100 |
Description of key information
The effect of the test item on the mobility of Daphnia magna was determined in a static study. The EL50 was determiend to be 2.5 mg/L at 48 h exposure.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.5 mg/L
Additional information
In the acute immobilisation test with Daphnia magna (STRAUS), the effects of the test item were determined according to Commission Directive 92/69/EEC (0.J. No. L383A, 29.12.92) Part C, Method 2 'Acute toxicity for Daphnia' andOECD 202. The study was conducted in a static system over a period of 48 hours with nominal concentrations prepared with WAF -1.25, 2.5, 5 and 10 mg/L. 20 daphnids per test concentration and control were tested in two replicates. The total organic carbon (TOC) of the test item was determined with TOC Analyzer. The biological endpoints were based on the nominal concentration.There was no immobilisation observed in twenty daphnids exposed to the test item concentration of 1.25 mg/L. A 100 % immobility was observed at two highest concentrations 5 and 10 mg/L tested. The estimated EL50 value (48 hours) of the test item based on the nominal concentration is 2.5 mg/L (geometric mean of EL0 and EL100).
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