Registration Dossier
Registration Dossier
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EC number: 209-060-4 | CAS number: 554-12-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Valid with restrictions. This is peer reviewed data where the test methodology and identity of the substance have been evaluated, and a reliable and representative value for the endpoint has been selected. No information on GLP status or test guideline followed is available.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Sax’s Dangerous Properties of Industrial Materials, 11th Edition, Volume 3
- Author:
- Lewis Sr., R.J.
- Year:
- 2 004
- Bibliographic source:
- Sax’s Dangerous Properties of Industrial Materials, 11th Edition, Volume 3
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Handbook data does not specify the method. Data from peer reviewed source.
- GLP compliance:
- not specified
- Test type:
- other: Handbook data does not specify the method. Data from peer reviewed source.
Test material
- Reference substance name:
- Methyl propionate
- EC Number:
- 209-060-4
- EC Name:
- Methyl propionate
- Cas Number:
- 554-12-1
- Molecular formula:
- C4H8O2
- IUPAC Name:
- methyl propanoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- other: rat, mouse and rabbit
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: rat
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 460 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: mouse
- Key result
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Effect level:
- 2 550 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: rabbit
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- According to the handbook data the acute oral LD50 to rats is 5000 mg/kg, the acute oral LD50 to mice is 3460 mg/kg and the lethal dose low to the rabbit is 2550 mg/kg.
- Executive summary:
According to the handbook data the acute oral LD50 to rats is 5000 mg/kg, the acute oral LD50 to mice is 3460 mg/kg and the lethal dose low to the rabbit is 2550 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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