Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 239-198-0 | CAS number: 15137-09-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From October 10 to 12, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna STRAUS
- Strain/clone:
- Justification for species other than prescribed by test guideline:
- Source: - Origin: Institut für Wasser-, Boden- und Lufthygiene (WaBoLu), 14195 Berlin, Germany; - Breeder: Noack Laboratorien GmbH, Käthe-Paulus-Str. 1, 31157 Sarstedt, Germany
- Age of parental stock (mean and range, SD): Less than 24 hours old
- - Feeding during test: no
ACCLIMATION
- Acclimation period: About 3.6 hours in the dilution water
- Type and amount of food: mix of unicellular green algae
- Feeding frequency: 5 times per week ad libitum - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 18 - 22 °C, constant within ± 1 °C
- Nominal and measured concentrations:
- 100 mg/l nominal concentration (0.754 geom. mean measured concentration).
Measured concentration at the start and at the end of exposure always between 5 and 6 %. - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beakers (4 (ID) x 7 (H) cm)
- Type (delete if not applicable): Closed (loosely covered with watch glasses)
- Material, size, headspace, fill volume: glass, 50 mL capacity
- Renewal rate of test solution (frequency/flow rate): solutions were renewed after 24 hours
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4 - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.754 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: nominal concentration = 100 mg/l
- Details on results:
- The measured concentration of cobalt at the start of the exposure (0 and 24 hours) and at the end of the exposure (24 and 48 hours) was between of 5 and 6% of the nominal concentration because most of the Co-complex remained undissociated.
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- EC50: 2.09 mg/l based on nominal concentration - Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 > 100 mg/l based on nominal concentration.
- Executive summary:
Method
In the acute immobilization test with Daphnia magna (STRAUS), the effects of the test item were determined at the test facility according to OECD guideline 202.
The study was conducted under semi-static conditions over a period of 48 hours with the limit concentration of 100 mg/L of the test item.The test solution was shaken manually until the solution was visually clear. The limit concentration was colorless and visually clear throughout the exposure.
Twenty daphnids (divided into 4 replicates with 5 daphnids each) were exposed to the limit concentration and the control.
The concentration of Cobalt, component of the test item, was analytically verified via spectrophotometric analysis in the fresh media of the limit concentration and in the control at the start of the exposure and at the renewal of the test solutions (0 and 24 hours) and in the 24-hours old media at the renewal and at the end of the test (24 and 48 hours).
The measured concentration of Cobaltat the start of the exposure (0 and 24 hours) and at the end of the exposure (24 and 48 hours) was between of 5 and 6% of the nominal concentration. The geometric mean measured concentration of Cobalt was 0.754 mg/L.
Since the recoveries of the measured Cobalt concentration were not within ± 20% of the nominal concentration,the effect concentrations are based on geometric mean measured concentration of Cobalt. Additionally, the effect levels are given based on the nominal concentration of the test item.
The validity criteria of the test guidelines were fulfilled.
Results
In the limit concentration 100 mg/Lof the test item, which corresponds to the geometric mean measured concentration of 0.754 mg/L of the component Cobalt, no effects on Daphnia magna were observed.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- From October 10 to 12, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- For the detailed read across justification see the document provided in section 13.2 of this dossier.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- assessment report
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna STRAUS
- Strain/clone:
- Justification for species other than prescribed by test guideline:
- Source: - Origin: Institut für Wasser-, Boden- und Lufthygiene (WaBoLu), 14195 Berlin, Germany; - Breeder: Noack Laboratorien GmbH, Käthe-Paulus-Str. 1, 31157 Sarstedt, Germany
- Age of parental stock (mean and range, SD): Less than 24 hours old
- - Feeding during test: no
ACCLIMATION
- Acclimation period: About 3.6 hours in the dilution water
- Type and amount of food: mix of unicellular green algae
- Feeding frequency: 5 times per week ad libitum - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 18 - 22 °C, constant within ± 1 °C
- Nominal and measured concentrations:
- 100 mg/l nominal concentration (0.754 geom. mean measured concentration).
Measured concentration at the start and at the end of exposure always between 5 and 6 %. - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beakers (4 (ID) x 7 (H) cm)
- Type (delete if not applicable): Closed (loosely covered with watch glasses)
- Material, size, headspace, fill volume: glass, 50 mL capacity
- Renewal rate of test solution (frequency/flow rate): solutions were renewed after 24 hours
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4 - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.754 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: nominal concentration = 100 mg/l
- Details on results:
- The measured concentration of cobalt at the start of the exposure (0 and 24 hours) and at the end of the exposure (24 and 48 hours) was between of 5 and 6% of the nominal concentration because most of the Co-complex remained undissociated.
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- EC50: 2.09 mg/l based on nominal concentration - Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 > 100 mg/l based on nominal concentration
- Executive summary:
Method
In the acute immobilization test with Daphnia magna (STRAUS), the effects of the test item were determined at the test facility according to OECD guideline 202.
The study was conducted under semi-static conditions over a period of 48 hours with the limit concentration of 100 mg/L of the test item.The test solution was shaken manually until the solution was visually clear. The limit concentration was colorless and visually clear throughout the exposure.
Twenty daphnids (divided into 4 replicates with 5 daphnids each) were exposed to the limit concentration and the control.
The concentration of Cobalt, component of the test item, was analytically verified via spectrophotometric analysis in the fresh media of the limit concentration and in the control at the start of the exposure and at the renewal of the test solutions (0 and 24 hours) and in the 24-hours old media at the renewal and at the end of the test (24 and 48 hours).
The measured concentration of Cobaltat the start of the exposure (0 and 24 hours) and at the end of the exposure (24 and 48 hours) was between of 5 and 6% of the nominal concentration. The geometric mean measured concentration of Cobalt was 0.754 mg/L.
Since the recoveries of the measured Cobalt concentration were not within ± 20% of the nominal concentration,the effect concentrations are based on geometric mean measured concentration of Cobalt. Additionally, the effect levels are given based on the nominal concentration of the test item.
The validity criteria of the test guidelines were fulfilled.
Results
In the limit concentration 100 mg/Lof the test item, which corresponds to the geometric mean measured concentration of 0.754 mg/L of the component Cobalt, no effects on Daphnia magna were observed.
Referenceopen allclose all
Description of key information
A study according to OECD 202 was conducted on Co(NH4)EDTA. A read across approach to CoNa2EDTA is reasonable (see the justification provided in section 13.2 of this dossier). Based on the nominal concentrations of the Co-EDTA-complex it can be stated that the EC50 is > 100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.