Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 640-410-2 | CAS number: 2594-75-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No data is available to assess the acute oral toxicity of the target substance Methyl-tris acetonoximo-silane. Thus, available data from a suitable read-across partner are used. In an acute oral toxicity study (OECD 423) with 2-propanone, 2,2’,2”-[O,O’,O”-(ethylsilylidyne)trioxime] no mortality has been reported at a dose of 2500 mg/kg bw. Thus, the oral LD50 can considered to be greater than 2500 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The source compound EAC3 (2-propanone, 2,2’,2”-[O,O’,O”-(ethylsilylidyne)trioxime], EC No. 611-631-1) is considered a suitable read across partner for the target substance MAC (CAS 2594-75-4). This read-across is based on the hypothesis that source and target substances have similar toxicological properties because:
- structural similarity of the target and the source substances (the presence or absence of additional functional groups or substituents that could influence the behaviour of a chemical),
- similarity in physico-chemical profile of the source and target substances (rapid decomposition in water under cleavage of the same substance (acetone oxime)).
Both substances are similar in terms of the substitution pattern at the silicon atom (i.e. acetoneoximo and methyl group(s)). Both substances exhibit consequently similar physico-chemical properties (rapid decomposition in water, decomposition upon heating to determine boiling point). - Reason / purpose for cross-reference:
- read-across source
- Preliminary study:
- n.a.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- EAC3 did not cause mortality at a dose level of 2500 mg/kg bw.
- Clinical signs:
- other: Treatment with EAC3 at the dose level of 2500 mg/kg bw caused decreased activity (6/6), hunched back (6/6), prone position (4/6), incoordination (6/6), piloerection (5/6) and creeping gait (3/6). All animals were symptom free from three days after the tre
- Gross pathology:
- No macroscopic observations were present at a dose level of 2500 mg/kg bw.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study in rats conducted according to OECD 423 no mortality occurred at the high dose of 2500 mg/kg bw. Hence, the LD50 value was determined to be greater than 2500 mg/kg bw.
- Executive summary:
In an acute oral toxicity study (acute toxic class method, OECD 423), two groups of fasted, 10-11 weeks old, female Wistar rats (3 rats/group) were given a single oral dose of the test item (92.13% purity) in PEG 400 at the dose of 2500 mg/kg bw and were observed for 14 days. All animals survived until the end of the study showing only mild signs of toxicity. The most relevant clinical findings were decreased activity (6/6), hunched back (6/6), prone position (4/6), incoordination (6/6), piloerection (5/6) and creeping gait (3/6). All animals were symptom free from three days after the treatment.
Throughout the 14-day observation period, the body weight showed no indication of a test item-related effect. At necropsy, no treatment-related macroscopic findings were observed in any animal of any step. Based on the results from this study, the oral LD50 in rats is considered to exceed 2500 mg/kg bw.
This information is used in a read-across approach in the assessment of the target substance.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- GLP guideline study
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No data is available to assess the acute oral toxicity of the target substance Methyl-tris acetonoximo-silane. Thus, available data from the suitable read-across partner 2-propanone, 2,2’,2”-[O,O’,O”-(ethylsilylidyne)trioxime] are used.
In an acute oral toxicity study (acute toxic class method, OECD 423), two groups of fasted, 10-11 weeks old, female Wistar rats (3 rats/group) were given a single oral dose of the test item (92.13% purity) in PEG 400 at the dose of 2500 mg/kg bw and were observed for 14 days. All animals survived until the end of the study showing only mild signs of toxicity. The most relevant clinical findings were decreased activity (6/6), hunched back (6/6), prone position (4/6), incoordination (6/6), piloerection (5/6) and creeping gait (3/6). All animals were symptom free from three days after the treatment.
Throughout the 14-day observation period, the body weight showed no indication of a test item-related effect. At necropsy, no treatment-related macroscopic findings were observed in any animal of any step. Based on the results from this study, the oral LD50 in rats is considered to exceed 2500 mg/kg bw.
Justification for classification or non-classification
Based on the available data, the target substance Methyl-tris acetonoximo-silane does not warrant classification for acute toxicity in accordance with regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.