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Diss Factsheets
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EC number: 617-560-2 | CAS number: 84377-83-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No guideline was specified. Dosing by gavage of the test substance, suspended in water for irrigation, to groups of 10 male and female mice to determine toxic effects from oral exposure to the substance.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- 1-{[(6R,7R)-7-[(2Z)-2-({[1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl]oxy}imino)-2-{2-[(triphenylmethyl)amino]-1,3-thiazol-4-yl}acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}pyridin-1-ium
- EC Number:
- 617-560-2
- Cas Number:
- 84377-83-3
- Molecular formula:
- C45H44O7S2.5/2(C3H7NO)
- IUPAC Name:
- 1-{[(6R,7R)-7-[(2Z)-2-({[1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl]oxy}imino)-2-{2-[(triphenylmethyl)amino]-1,3-thiazol-4-yl}acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}pyridin-1-ium
- Reference substance name:
- N,N-dimethylformamide
- EC Number:
- 200-679-5
- EC Name:
- N,N-dimethylformamide
- Cas Number:
- 68-12-2
- Molecular formula:
- C3H7NO
- IUPAC Name:
- N,N-dimethylformamide
- Test material form:
- solid: particulate/powder
- Details on test material:
- Moisture content 0.16% w/w (Karl FIscher) as supplied to laboratory.
Batch Number: G309569
Constituent 1
additive 1
Test animals
- Species:
- mouse
- Strain:
- other: CRH (Glaxo Group Research Limited, Harefield Breeding Unit)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight range: 16-20g.
Not starved prior to treatment
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- Irrigation water
- Details on oral exposure:
- Material was formulated as a suspension in Water for Irrigation, using a Silverson blender, and dosed by gavage at a dose volume of 1ml/20g, to groups of 10 male and 10 female mice.
- Doses:
- 1ml suspension / 20 g of animal
1000 mg/kg - No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- Observation period: 14 days
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No animals died due to ingestion of the test material.
- Clinical signs:
- other: Nothing abnormal detected
- Gross pathology:
- No significant lesions were seen at autopsy although Kidneys of 5 males and 6 females were slightly pale. These tissues were submitted for histopathological examination and were found to be microscopically normal.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- 'Trityl DMF solvate' has a low order of acute oral toxicity in mice with an LD50 value in excess of 1000 mg/kg. No signs of toxicity were seen at that dose level.
- Executive summary:
Dosing by gavage of the test substance, suspended in water for irrigation, to groups of 10 male and female mice to determine toxic effects from oral exposure to the substance, showed no toxicity up to a dosage of 1000 mg/kg body weight.
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