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Diss Factsheets
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EC number: 701-475-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- In the environment, all lithium borate substances in the category rapidly dissociate and release the same common compound, boric acid as a result of relevant transformation pathways (e.g. hydrolytic, oxidative, digestive or metabolic) at environmentally relevant conditions (i.e., pH and concentration). This boric acid component of the salt is expected to drive the ecotoxicological and environmental fate properties of all the lithium borate substances.
Literature evidence is documented in the attached category approach document.
Boric acid, [B(OH)3], is a very weak, monobasic acid that acts as a Lewis acid by accepting a hydroxyl ion to form the borate anion, [B(OH)4]-. Therefore at higher concentrations and pH levels greater than 9.2, the borate anion [B(OH)4]- becomes predominant.
B(OH)3 + 2H2O¿[B(OH)4]- + H3O+
Therefore, at the near neutral pH of most environmental and ecotoxicological systems and at low concentrations (<0.025 mol B/L), the neutral mononuclear species (B(OH)3) will dominate and only a small proportion of boron will exist as the borate monoanion, B(OH)4- (WHO, 1998).
Based on existing information sourced from the scientific and regulatory literature it is concluded that all the lithium borate substances in this category are expected to react similarly in the environment, forming boric acid if exposed to water or moist soils in the environment. As a result, read-across to dilithium tetraborate is proposed for this endpoint for the REACH registration of the UVCB-Reaction products of boric acid and lithium hydroxide. - Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 36 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: yield inhibition
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: based on biological
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: based on statistical significance
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: yield inhibition
- Remarks on result:
- other: based on biological
- Validity criteria fulfilled:
- yes
- Conclusions:
- In conclusion, the UVCB-Reaction products of boric acid and lithium hydroxide is expected to reduce the growth rate and inhibit the yield of this fresh water algae species significantly at test concentrations of 18 mg/L and higher in an analogous manner to dilithium tetraborate.
- Executive summary:
The effects of dilithium tetraborate on Pseudokirchneriella subcapitata were determined by an experimental study conducted according to OECD guideline No. 201.
Growth rate and yield were in the range of the controls at the lowest test concentration during the 72-hour test period, whereas at higher concentrations growth rate and yield were increasingly inhibited. Statistically significant inhibition of growth rate and yield was found at test concentrations of 18 mg/L and higher. The inhibition of growth rate observed at the concentrations of 18 and 32 mg/L was however, considered biologically not relevant (i.e. were <10%). Therefore, the NOEC (inhibition of growth rate based on biological relevance) = 32 mg/L.
In the environment, all lithium borate substances in the category rapidly dissociate and release the same common compound, boric acid as a result of relevant transformation pathways (e.g. hydrolytic, oxidative, digestive or metabolic) at environmentally relevant conditions (i.e., pH and concentration). This boric acid component of the salt is expected to drive the ecotoxicological and environmental fate properties of all the lithium borate substances.
Therefore, the UVCB-Reaction products of boric acid and lithium hydroxide will inhibit the growth and yield of Pseudokirchneriella subcapitata in a similar manner. In conclusion, lithium tetrahydroxyborate is expected to reduce the growth rate and inhibit the yield of this fresh water algae species significantly at a nominal test concentration of 18 mg/L or greater.
Reference
Description of key information
The effects of dilithium tetraborate on Pseudokirchneriella subcapitata were determined by an experimental study conducted according to OECD guideline No. 201.
Growth rate and yield were in the range of the controls at the lowest test concentration during the 72-hour test period, whereas at higher concentrations growth rate and yield were increasingly inhibited. Statistically significant inhibition of growth rate and yield was found at test concentrations of 18 mg/L and higher.
In the environment, all lithium borate substances in the category rapidly dissociate and release the same common compound, boric acid as a result of relevant transformation pathways. Therefore, lithium tetrahydroxyborate will inhibit the growth and yield of Pseudokirchneriella subcapitata in a similar manner. In conclusion, the UVCB-Reaction products of boric acid and lithium hydroxide is expected to reduce the growth rate and inhibit the yield of this fresh water algae species significantly at a nominal test concentration of 18 mg/L or greater.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
- EC10 or NOEC for freshwater algae:
- 32 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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