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EC number: 604-344-8 | CAS number: 143314-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1H-imidazolium, 1-ethyl-3-methyl-, acetate
- Cas Number:
- 143314-17-4
- Molecular formula:
- C6 H11 N2 .C2 H3 02
- IUPAC Name:
- 1H-imidazolium, 1-ethyl-3-methyl-, acetate
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): 1-Ethyl-3-methylimidazolium acetate
- Physical state: liquid
- Analytical purity: 95 %
- Lot/batch No.: 08-009; PSN 06/0363-2
- Expiration date of the lot/batch: Stability under storage conditions over test period was guaranteed by the sponsor.
- Storage condition of test material: Room temperature
- Other: color: brown, clear
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, Sulzfeld, Germany
- Age at study initiation: about 8 (males) and 12 (females) weeks old
- Weight at study initiation: mean for high dose: 236.4 g (male), 205.4 g (female) and for low dose: 260.4 g (male), 205.0 (female)
- Housing: Makrolon cage, type III; single housing
- Diet: VRF1(p); SDS Special Diet Services, Altrip, germany; ad libitum
- Water: Tap water ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C +/- 3°C
- Humidity (%): 30-70%
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 40 cm2
- % coverage: at least 10 % of the body surface
- Type of wrap if used: semiocculsive dressing for 24 h
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with warm water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 5000 mg/kg bw (4.5 ml/kg bw); 2000 mg/kg bw (1.80 ml/kg bw)
- Concentration (if solution): undiluted
- Constant concentration used: yes
VEHICLE
no vehicle - Duration of exposure:
- 24 h
- Doses:
- 5000 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily for mortality; clinical observations: several times at day of administration and at least once daily thereafter each working day; scoring of skin findings: 30-60 min after removal of the semiocclusive dressing (day 1), weekly thereafter; bw: weekly
- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 - < 5 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 - < 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- - 5000 mg/kg bw test group: 5/5 females and 1/5 males were found dead within 1h after application.
- 2000 mg/kg bw test group: 1/5 females was found dead directly after application, no mortality among the males - Clinical signs:
- other: SYSTEMIC EFFECTS: - 5000 mg/kg bw test group: no clinical observation of the females (died within first hour); one male that died: poor general state, gasping, twitching, clonic convulsions; surviving males: impaired and poor general state, dyspnoea, gas
- Gross pathology:
- - 5000 mg/kg bw test group: Animals that died (1 male, 5 females) showed no macroscopic pathologic abnormalities.
- 2000 mg/kg bw test group: 1 female that died showed yelloish discoloration of content in the small intestine.
No macroscopic pathologic abnormalities were noted in the animals examined at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Due to the LD50 (dermal, rat) >2000 and <5000 mg/kg bw no classification is required according to Annex VI of Directive 67/548/EWG (DSD) or Annex I of Directive 1272/2008 (EU-GHS).
- Executive summary:
In the GLP, OECD402 study (BASF SE, 2010) Wistar rats were exposed once to 2000 and 5000 mg/kg bw of the test substance and observed for 14 days. 5/5 females and 1/5 male died in the high dose group and 1/5 females and 0/5 males died in the low dose group. The following clinical observations were found in the surviving animals: impaired and poor general state, dyspnoea, gasping, chromodacryorrhea and lateral position from hour 1-5 after administration in the high dose group; impaired and poor general state, dyspnoea, staggering, chromodacryorrhea, abdominal position and flat respiration from hour 0 - to 5 after administration in the low dose group. Local effects such as erythema, edema and parital severe incrustations and scaling were found in all groups but reversed within observation time. Macroscopic pathological abnormalities were found only in the one female exposed to 2000 mg/kg bw yellowish discoloration of content in the small intestine. BW of the survining animals increased throughout the study period within normal range. The dermal LD50 in rats (both sexes combined) was <2000 and < 5000 mg/kg bw.
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