Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1)

Explosiveness

Link to relevant study record(s)

Reference

Endpoint:

explosiveness, other

Type of information:

other: Expert assessment

Adequacy of study:

key study

Study period:

January 26, 2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: An expert assessment for explosive behaviour based on an examination of the molecular structure (e.g. functional groups) and composition of the substance and its components, along with available literature and hazard information

Qualifier:

no guideline followed

Principles of method if other than guideline:

An expert assessment for explosive behaviour based on an examination of the molecular structure (e.g. functional groups) and composition of the substance and its components, along with available literature and hazard information

GLP compliance:

no

Key result

Parameter:

other: Expert assessment

Remarks:

Explosiveness

Remarks on result:

other: Does not possess chemical functionality associated with explosive properties

Assessment of the Reaction Mass of Morpholine and 6-[(p-Tosyl)amino]hexanoic Acid, Compound with Morpholine (1:1) for Functionality Typically Associated with Explosive Properties:

Functional Group*	Comments/Conclusions
	6-[(p-Tosyl)amino]hexanoic acid, compound with 2-aminoethanol (1:1)	Morpholine	Water
C-C unsaturation (acetylenes, acetylides, 1,2-dienes)	The only C-C unsaturation present is the di-substituted aromatic ring; however, it does not carry substituents, such as nitro groups that are known to give rise to explosive behaviour.	Not present	Not present
C-Metal and N-Metal (Grignard reagents, organo-lithium compounds)	Not present	Not present	Not present
Contiguous N atoms (azides, aliphatic azo compounds, diazonium salts, hydrazines	Not present	Not present	Not present
Contiguous O atoms (peroxides, ozonides)	Not present	Not present	Not present
N-O (hydroxylamines, nitrates, nitro compounds, nitroso compounds, N-oxides)	Not present	Not present	Not present
N-Halogen (chloramines, fluoroamines)	Not present	Not present	Not present
O-Halogen (chlorates, perchlorates)	Not present	Not present	Not present

*Taken from Table A6.1 in Appendix 6 of the UN Recommendations on the Transport of Dangerous Goods: Manual of Tests and Criteria, 6th Ed.

Interpretation of results:

GHS criteria not met

Conclusions:

Following an expert assessment based on available literature, hazard information, and experimental data, it has been concluded that the reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) does not have any chemical functionality that is associated with explosive properties. Further testing is not needed according to Column II of REACH Annex VII.

Executive summary:

The explosiveness of the reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) was determined in an expert assessment based on examination of the molecular structure and composition of the substance using relevant literature and data. Structural motifs in organic material that are associated with explosive potential were identified in Appendix 6 of the UN Recommendations on the Transport of Dangerous Goods: Manual of Tests and Criteria, 6th Ed. and were used as a basis for review. Section 2.1.4.2 of the CLP regulation (EC 1272/2008) was referred to in order to structure a screening procedure, as well as hazard information for two main constituents of the substance: 6-[(p-tosyl)amino]hexanoic acid and morpholine. Only one of the functional groups listed in Appendix 6 is present in the registration substance, namely C-C unsaturation (acetylenes, acetylides, 1,2-dienes) within the component 6-[(p-tosyl)amino]hexanoic acid, compound with 2-aminoethanol (1:1). However, the only C-C unsaturation present is the di-substituted aromatic ring and it does not carry substituents, such as nitro groups, that are known to give rise to explosive behaviour. As there were no structural motifs associated with explosive behaviour, it is suggested that the reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not predisposed to explosive behaviour and further testing is not necessary (Column II of REACH Annex VII).

Description of key information

Following an expert assessment based on available literature, hazard information, and experimental data, it has been concluded that the reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) does not have any chemical functionality that is associated with explosive properties. Further testing is not needed according to Column II of REACH Annex VII.

Key value for chemical safety assessment

Explosiveness:

non explosive