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EC number: 217-533-1 | CAS number: 1879-09-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1 June to 19 June 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Study is designed only as a screening study.
- GLP compliance:
- no
- Specific details on test material used for the study:
- No further details specifiedin the study report.
- Analytical monitoring:
- not specified
- Details on sampling:
- Not specified in the report.
- Vehicle:
- yes
- Details on test solutions:
- Preliminary solution in 1% v/v Tween 80-acetone.
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Test Species: Rainbow trout (Oncorhynchus mykiss).
Length: 4.4 ± 0.3 cm.
Weight: 1. 19 ± 0. 30 g Loading: 0.60 g bodyweight/litre.
Supplier: Parkwood Trout Farm, Kent, U.K.
Screening study: 2 fish
Main study: 10 fish - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- No post exposure observation period specified in the study report.
- Hardness:
- Approximately 50 mg/l as CaC03
- Test temperature:
- 14.0°C
- pH:
- Not specified
- Dissolved oxygen:
- Not specified
- Salinity:
- Not applicable
- Conductivity:
- Not specified
- Nominal and measured concentrations:
- Nominal concentrations:
Range finding study: 0.10, 1.0, 10 mg/l
Main study: 1.0 mg/l - Details on test conditions:
- Method of Preparation: Preliminary solution in 1% v/v Tween 80-acetone.
Media Renewal: Daily.
Medication: None.
Test Water: Dechlorinated tap water (Sodium thiosulphate).
Test Vessels: 20 l.
Aeration: Yes. - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 - < 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- 2/2 deaths at 10 mg/l; 0/10 deaths at 1 mg/l. LC50 considered to lie between 1 and 10 mg/l.
- Results with reference substance (positive control):
- No reference substance utilised.
- Sublethal observations / clinical signs:
Range Finding Study – Dates: 1 – 5 June 1992.
Concentration (mg/l)
Cumulative Mortality (initial population = 2)
24 Hours
48 Hours
72 Hours
96 Hours
Control
0
0
0
0
Solvent Control
0
0
0
0
0.10
0
0
0
0
1.0
0
0
0
0
10
2
2
2
2
Definitive Study – Dates: 15 – 19 June 1992
Concentration (mg/l)
Cumulative Mortality (initial population = 10)
24 Hours
48 Hours
72 Hours
96 Hours
Control
0
0
0
0
Solvent Control
0
0
0
0
1.0 R1
0
0
0
0
1.0 R2
0
0
0
0
R1– R2: Replicates R1– R2
- Validity criteria fulfilled:
- yes
- Conclusions:
- 96h LC50 >1.0 mg/l, <10 mg/l.
- Executive summary:
96h LC50 >1.0 mg/l, <10 mg/l.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Qualifier:
- according to guideline
- Guideline:
- other: "Testing Method Concerning New Chemical Substances, etc.,”
- Deviations:
- not specified
- Principles of method if other than guideline:
- This study was performed in accordance with "Testing Method Concerning New Chemical Substances, etc.,” the Joint Notice of Director of Pharmaceutical and Food Safety Bureau, the Ministry of Health, Labour and Welfare, Director of Manufacturing Industries Bureau, the Ministry of Economy, Trade and Industry, and Director of Environmental Policy Bureau, the Ministry of the Environment (November 21, 2003, Yakushoku-hatsu No. 1121002, Heisei 15-11-13 Seikyoku No. 2, Kanpoki-hatsu No. 031121002, final revision partly on November 20, 2006).
- GLP compliance:
- yes
- Specific details on test material used for the study:
- No further details specified in the study report.
- Analytical monitoring:
- yes
- Details on sampling:
- Test concentration (nominal): control, 0.40, 0.63, 1.0, 1.6, 2.5, 4.0 mg/L
common ratio; 1.6 - Vehicle:
- not specified
- Details on test solutions:
- Not specified
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- Test organism: killifish (Oryzias laptipes)
Number of test organism: 10 fish/test area
Lighting: room light, 16 hours light/8 hours dark
Feeding: no feeding - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- No post exposure observation period specified in the report.
- Hardness:
- Not specified.
- Test temperature:
- 24±1°C
- pH:
- Not specified
- Dissolved oxygen:
- Not specified
- Salinity:
- Not applicable.
- Nominal and measured concentrations:
- Nominal concentrations
- Details on test conditions:
- Exposure method: semi-static water (all test solution was renewed at 48 hours.)
Exposure period: 96 hours
Volume of test solution: 5 L/vessel
Replicates: 1 vessel/test area
Aeration: none
pH: pH adjustment of the test solution was not performed. - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No further details on results specified in the report
- Results with reference substance (positive control):
- Reference substance not used in this study
- Reported statistics and error estimates:
- The variance of test substance concentration was considered to be decrease due to volatilization. Therefore, time-weighted average (the arithmetical mean of logarithmic means at the start of exposure and 48 hours before water renewal, and 48 hours after water renewal and at the end of exposure) was calculated for each effect concentration.
- Validity criteria fulfilled:
- yes
- Conclusions:
- 50% lethal concentration
24-hour 50% lethal concentration (LC50): 2.9 mg/L (95% confidence limit: 2.3-3.8 mg/L), 48-hour 50% lethal concentration (LC50): 2.7 mg/L (95% confidence limit: 2.3-4.7 mg/L), 72-hour 50% lethal concentration (LC50): 2.7 mg/L (95% confidence limit: 2.0-4.0 mg/L), 96-hour 50% lethal concentration (LC50): 2.5 mg/L (95% confidence limit: 1.9-3.7 mg/L) - Executive summary:
This study was performed in accordance with "Testing Method Concerning New Chemical Substances, etc.,” the Joint Notice of Director of Pharmaceutical and Food Safety Bureau, the Ministry of Health, Labour and Welfare, Director of Manufacturing Industries Bureau, the Ministry of Economy, Trade and Industry, and Director of Environmental Policy Bureau, the Ministry of the Environment (November 21, 2003, Yakushoku-hatsu No. 1121002, Heisei 15-11-13 Seikyoku No. 2, Kanpoki-hatsu No. 031121002, final revision partly on November 20, 2006).
50% lethal concentration
24-hour 50% lethal concentration (LC50): 2.9 mg/L (95% confidence limit: 2.3-3.8 mg/L),
48-hour 50% lethal concentration (LC50): 2.7 mg/L (95% confidence limit: 2.3-4.7 mg/L),
72-hour 50% lethal concentration (LC50): 2.7 mg/L (95% confidence limit: 2.0-4.0 mg/L),
96-hour 50% lethal concentration (LC50): 2.5 mg/L (95% confidence limit: 1.9-3.7 mg/L)
On the basis of the results noted in the study, classification under the Dangerous Substance Directive (67/548/EEC) and the CLP Regulation (EC No 1272/2008 is as follows:
N; R51/53 Dangerous for the environment; Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Chronic aquatic toxicity, Category 2; H411: Toxic to aquatic life with long lasting effects.
Referenceopen allclose all
Description of key information
Key value determined using Japaneses test guidelines.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 2.5 mg/L
Additional information
Main study:
50% lethal concentration
24-hour 50% lethal concentration (LC50): 2.9 mg/L (95% confidence limit: 2.3-3.8 mg/L),
48-hour 50% lethal concentration (LC50): 2.7 mg/L (95% confidence limit: 2.3-4.7 mg/L),
72-hour 50% lethal concentration (LC50): 2.7 mg/L (95% confidence limit: 2.0-4.0 mg/L),
96-hour 50% lethal concentration (LC50): 2.5 mg/L (95% confidence limit: 1.9-3.7 mg/L)
Non-GLP Supporting study:
96h LC50 >1.0 mg/l, <10 mg/l.
On the basis of the results noted in the study, classification under the CLP Regulation (EC No 1272/2008 is as follows:
Chronic aquatic toxicity, Category 2; H411: Toxic to aquatic life with long lasting effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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