Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 610-641-3 | CAS number: 512802-65-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April to June 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Carried out according to guidelines dated from 1984. Analytical determination of exposure concentrations not included. Other data deficiencies also evident.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- Version Part I, 1984.
Also stated according to EC Directive 84/449 C.2, 1989 - GLP compliance:
- yes
- Specific details on test material used for the study:
- Other names: Marlosoft PP
Stability: < 1 year
Appearance: yellowish liquid
Date of manufacture: 21/05/1992
Sample number: 1336/920817
ID number: 3633/81451
Purity/ingredients: dry residue 99.97%, C:73,14%; 7 mol% glycerol (derivative), 45 mole %fatty acid derivative; 48 mol of propylene oxide. - Analytical monitoring:
- no
- Details on sampling:
- No details provided
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: stock prepared in freshwater and stirred for 18 hours. Solution filtered and the carbon content measured at 42.2mg/L, which related to a concentration of 58 mg/L.
- Controls: 1 control
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): None detailed - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain/clone: Straus, clone 5
- Source: own breed
- Age of parental stock (mean and range, SD): not stated,
- Feeding during test: not fed during test
- Food type: not stated
METHOD FOR PREPARATION AND COLLECTION OF EARLY INSTARS OR OTHER LIFE STAGES:
- Mothers are reared approximately 24 hours before trial isolated and separated from the breed hold. The hatchlings hatched overnight are transferred to test water (composition
see Tab. 5 in the appendix) and for the test.. - Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- assumed the test is a static test based on the method details, although not specifically stated in the report
- Hardness:
- Not determined
- Test temperature:
- 20±1 ˚C
- pH:
- 7.7 to 7.8 (measured at end of test)
- Dissolved oxygen:
- 7.7 to 7.9 (measured at end of test)
- Salinity:
- Not determined
- Conductivity:
- Not determined
- Nominal and measured concentrations:
- Nominal concentrations: 6.38, 9.28, 12.76, 18.56, 26.10, 37.12, 52.20 mg/L.
All concentrations refer to the anhydrous product concentrations.
Measured concentrations: not determined - Details on test conditions:
- TEST SYSTEM
- Test vessel: round arch glasses, 10 ml
- Material, size, headspace, fill volume: not stated
- Aeration: not stated
- Type of flow-through (e.g. peristaltic or proportional diluter): not stated, but assumed static
- Renewal rate of test solution (frequency/flow rate): not stated
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 5
- No. of vessels per vehicle control (replicates): 4
- Biomass loading rate: 1 individual per 2 ml
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: synthetic freshwater
- Only details provided on the synthetic water were: CaCl2 x H2O - 294mg/L, MgSO4 x 7H2) - 123 mg/L, NaHCO3 - 63mg/L, KCl - 5.5mg/L.
OTHER TEST CONDITIONS
- Adjustment of pH: Not stated
- Photoperiod: stated as dark
- Light intensity: Not stated
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- immobilisation rates - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 52.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 52.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- See Table 1 for details on the number of mobile and immobile daphnia at each concentration.
Immobilisation is only considered significant at >10%. - Results with reference substance (positive control):
- With the reference substance, 30 and 100% immobilisation was observed at concentrations of 0.9 and 1.9 mg/L respectively.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The toxicity of propoxylated palm oil to Daphnia magna after 48 hours was assessed. A NOEC and EC100 of 52.2 and >52.2 mg/L respectively were determined. The test substance is not toxic to aquatic organisms at the limit of solubility.
- Executive summary:
The short term toxicity of propoxylated palm oil (CAS number 512802-65-2) was assessed using Daphnia magna over a 48 hour period. The study was conducted according to OECD 202 Guideline (version 1984), and according to GLP. Exposure concentrations were not measured in the test and some study details are limited, therefore the study is rated as a Klimisch 2, however the study is considered reliable. Seven exposure concentrations were assessed, in addition to controls ranging from 6.38 to 52.20 mg/L.
After 48 hours, no immobilisation was observed in any of the test concentrations. The NOEC and EC100 of 52.2 and >52.2 mg/L were provided. An EC50 of >52.2 mg/L is calculated, however the test substance is not toxic to aquatic organisms at the limit of solubility.
Reference
Table 1. Number of mobile and immobile dapnia magna at 24 and 48 hours
Nominal exposure concentration (mg/L) |
24 hours |
48 hours |
||||
Number |
Percentage % |
Number |
Percentage % |
|||
Mobile |
Immobile |
Immobile |
Mobile |
Immobile |
Immobile |
|
Control |
20 |
0 |
0 |
19 |
1 |
5 |
6.38 |
19 |
1 |
5 |
19 |
1 |
5 |
9.28 |
21 |
0 |
0 |
21 |
0 |
0 |
12.76 |
21 |
0 |
0 |
21 |
0 |
0 |
18.56 |
21 |
0 |
0 |
21 |
0 |
0 |
26.10 |
20 |
0 |
0 |
20 |
0 |
0 |
37.12 |
21 |
0 |
0 |
21 |
0 |
0 |
52.20 |
20 |
0 |
0 |
20 |
0 |
0 |
Description of key information
The short term toxicity of propoxylated palm oil (CAS number 512802-65-2) was assessed using Daphnia magna over a 48 hour period. After 48 hours, no immobilisation was observed in any of the test concentrations. The NOEC and EC100 of 52.2 and >52.2 mg/L were provided. An EC50 of >52.2 mg/L has been determined from this information, however the test substance is not toxic to aquatic organisms at the limit of solubility.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 52.2 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.