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EC number: 252-091-3 | CAS number: 34562-31-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral LD50 > 500 mg/kg bw, dermal LD50 > 1000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: U.S. 52 FR 42961, 49 CFR 173.132
- Principles of method if other than guideline:
- This study was performed under the DOT guidelines specified in 52 FR 42961, 49 CFR 173.132
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Albino rats, five males and five females
All weighed between 200 and 300g - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- All rats were administered a single Sponsor specified dose of the test substance by oral gavage.
- Doses:
- 500 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- All animals received a single dose of 500 mg/kg bw of the test substance by oral gavage. The dose volume did not exceed 1 ml/100 g body weight. Following treatment, the animals were observed for clinical signs of toxicity at least once daily for 14 days. Body weights were determined on Day 0, Day 7, and Day 14.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1 rat died on Day 2 of the observation period.
- Clinical signs:
- other: Two of the test animals exhibited clinical signs
- Gross pathology:
- The animal that died during the study was observed at necropsy as having a moderately pale liver. All other animals were observed as having no visible lesions at necropsy
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- > 300 mg/kg as per Regulation EC No. 1272/2008
- Conclusions:
- The oral LD50 of the test material is greater than 500 mg/kg bw in rats.
Reference
The oral LD50 of the test material is ≥500 mg/kg bw according to a U.S. DOT guideline study.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 500 mg/kg bw
- Quality of whole database:
- adequate
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: U.S. 52 FR 42961, 49 CFR 173.132
- Principles of method if other than guideline:
- This study was performed under the DOT guidelines specified in 52 FR 42961, 49 CFR 173.132
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Ten albino ratts (5 male and 5 female) were used in the study
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Dorsums were clipped free of hair prior to application of the test article. The test article was introduced to not less than 10% of the total body surface area (15.5cm x 15.5cm) The test article was held in contact with the skin with prous gauze dressing and non-irritating tape. The animals were further wrapped with Vetrap bandaging for the exposure period.
- Duration of exposure:
- 24 hours
- Doses:
- 1000 mg (1 g)/kg bw, as specified by sponsor
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- The duration of the occlusive exposure was 24 hours. At the end of the exposure period, the test sites were rinsed with water and the animals observed for signs of erythema and edema. The animals were then observed daily for clinical signs of toxicity for a 14 day observation period. At the end of the observation period, a gross necropsy was performed on all animals.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Remarks:
- The LD50 may be > 2000 mg/kg bw
- Mortality:
- None observed
- Clinical signs:
- other: No signs of toxicity were observed in any of the animals. However, erythema was noted on all animals after the 24h exposure period and was reversed on all animals by Day 5.
- Gross pathology:
- No unusual observation recorded in gross pahtologies.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 of the test material is > 1000 mg/kg bw, with no observed lethality for 14 days after exposure. This was evaluated as "non-toxic" according to the U.S. DOT guidelines.
Reference
Erythema was noted on all animals after the 24h exposure period, but resolved in all animals by day 5.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 000 mg/kg bw
- Quality of whole database:
- adequate
Additional information
Justification for classification or non-classification
The substance has an oral LD50 > 500 mg/kg bw; this meets the criteria for classification as acute oral toxicity 4 (300 mg/kg > LD50 < 2000 mg/kg). The dermal LD50 is > 1000 mg/kg bw and evaluated as "non-toxic" with lethality reported, though this single dose is not sufficiently high to meet GHS requirements for non-classification. Due to the absence of any animal deaths at 1000 mg/kg bw, and the evaluation of "non-toxic" according to U.S. DOT guidance, the substance is not classified for acute toxicity by the dermal route. However, due to an indication of skin irritation and severe damage to the eye, protection from dermal exposure is recommended by the use of personal protective equipment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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