Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-329-8 | CAS number: 3068-78-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Additional information
Suitable experimental data testing the toxicity of N-[3-(trimethoxysilyl)propylcyclohexylamine] (CAS 3068-78-8) towards fish and aquatic microorganisms were available. For the two remaining trophic levels, aquatic invertebrates and algae read across from the structurally analogous substance N-{[Diethoxy(methyl)silyl]methyl}cyclohexanamine (CAS 27445-54-1) was performed.
Information on the read across approach can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13.
All studies with the target and the source substances were performed according to the appropriate OECD or EU guidelines and GLP standards.
The study testing the acute toxicity of N-[3-(trimethoxysilyl)propylcyclohexylamine] (CAS 3068-78-8) towards fish did not show any toxic effects and resulted into an LC50 (96 h) of > 100 mg/L (nominal). An EC50 (48 h) of > 210 mg/L (nominal) was determined in the study testing the effects of the source substanceN-{[Diethoxy(methyl)silyl]methyl}cyclohexanamine (CAS 27445-54-1)on the mobility of Daphnia magna. The study testing the effects of the source substance on the growth rate of the algae Scenedesmus subspicatus resulted in an ErC50 (72 h) value of 40.71 mg/L and an ErC10 (72 h) of 16.88 mg/L (nominal).
Furthermore the influence of the test item N-[3-(trimethoxysilyl)propylcyclohexylamine] (CAS 3068-78-8) on the respiration rate of activated sludge was tested according to the OECD guideline 209 and GLP standards. The study resulted into an EC20 (3 h) of 203 mg/L (nominal).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)