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EC number: 202-815-9 | CAS number: 100-06-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- The open epicutaneous test (OET), a predictive test procedure in the guinea pig for estimation of allergenic properties of simple chemical compounds, their mixtures and of finished cosmetic preparations
- Author:
- Klecak G
- Year:
- 1 979
- Bibliographic source:
- International Federation Societies Cosmetic Chemists, 9/18/79
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Version / remarks:
- Open Epicutaneous Test
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Modified non-occlusive Draize skin sensitsation test with one ocassion for induction (4 intradermal injections of 0.1 mL aliquots at 2.5-fold concentration of ICC)
- GLP compliance:
- no
- Type of study:
- Draize test
- Justification for non-LLNA method:
- Test performed 1979.
Test material
- Reference substance name:
- 4'-methoxyacetophenone
- EC Number:
- 202-815-9
- EC Name:
- 4'-methoxyacetophenone
- Cas Number:
- 100-06-1
- Molecular formula:
- C9H10O2
- IUPAC Name:
- 1-(4-methoxyphenyl)ethanone
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Not specified.
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, open
- Vehicle:
- not specified
- Concentration / amount:
- 100, 30, 10, 3 and 1% or lower
- Day(s)/duration:
- Not specified
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- epicutaneous, open
- Vehicle:
- not specified
- Concentration / amount:
- Not specified
- Day(s)/duration:
- Not specified
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- Not specified.
- Details on study design:
- PRELIMINARY STUDY
- Type of study: Irritation test
- Obejctive: To determine the animal irritating concentration and to derive the maximal non-irritant concentration (the highest concentration not inducing macroscopic signs of irritation in any of the animals in the specific test group) as baseline data for the main test
- Concentrations: 4 different concentrations
- Vehicle: Not specified
- Test groups: 1 group of test animals per concentration
- Application site: Left flank skin, skin clipped
- Occlusion: None (non-occlusive)
- Exposure: 24 hours
- Reading: After 24 hours
MAIN TEST
- Phases of the test procedure: Induction (21 daily open applications), challenge (on days 21 and 35)
- Concentrations: 100, 30, 10, 3 and 1% or lower
- Vehicle: Ethanol, acetone, water, vaseline, PEG and/or other suitable vehicles; not further specified
- Application site: Left flank skin, skin clipped
- Occlusion: None (non-occlusive)
- Exposure: Not specified
- Reading: Not specified - Challenge controls:
- Yes, one control group with 8 test animals.
- Positive control substance(s):
- no
Results and discussion
- Positive control results:
- Not applicable.
In vivo (non-LLNA)
Resultsopen allclose all
- Group:
- negative control
- Remarks on result:
- no indication of skin sensitisation
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 6%
- No. with + reactions:
- 0
- Total no. in group:
- 6
- Clinical observations:
- Not specified
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 6%
- No. with + reactions:
- 0
- Total no. in group:
- 6
- Clinical observations:
- Not specified
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- 6%
- No. with + reactions:
- 0
- Total no. in group:
- 6
- Clinical observations:
- Not specified
- Remarks on result:
- no indication of skin sensitisation
Any other information on results incl. tables
The results of the Open Epicutaneous Test (OET) were compared with those of the Kligman Human Maximization Test (HMT) by RIFM. The results of the OET coincided with those of the HMT: At a test concentration of 6.0% (purity of the test material >= 97%) no signs skin sensitisation was oberved.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item has no skin sensitising potential in an OET with guinea pigs.
- Executive summary:
An open epicutaneous test was conducted in guinea pigs. Induction consisted of 21 daily open applications to the shaved flank of 6-8 guinea pigs per group. One to six experimental and one control group was used. Open challenge applications were made on days 21 and 35. Reactions were read at 24, 48 and 72 hours. No further details were provided.
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