Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 293-766-2 | CAS number: 91082-52-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- - Principle of test: Groups of five male and five female rats received a single oral dose of the test substance. The animals were then observed daily for a period of 14 days.
- Short description of test conditions: Animals received a single oral dose of the test substance of 200, 600, 1000 or 2000 mg/kg, administered by gavage in corn oil at a standard volume of 10 mL/kg.
- Parameters analysed / observed: Animals were checked regularly for mortality and any sign of toxicity. At the end of the study, surviving animals were humanely killed and were examined by necropsy for any macroscopic abnormalities. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tar bases, coal, lutidine fraction
- EC Number:
- 293-766-2
- EC Name:
- Tar bases, coal, lutidine fraction
- Cas Number:
- 91082-52-9
- IUPAC Name:
- Tar bases, coal, lutidine fraction
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alderley Park SPF albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: colony maintained in the laboratory at Alderley Park, Cheshire, UK
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: not reported
- Weight at study initiation: bodyweight range 221-390 g for males and 198-253 for females
- Fasting period before study: 26 to 24 hours before dosing
- Housing: not reported
- Diet (e.g. ad libitum): not reported
- Water (e.g. ad libitum): not reported
- Acclimation period: not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not reported
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20-200 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg
- Justification for choice of vehicle: not reported
- Lot/batch no. (if required): not reported
- Purity: not reported
- Doses:
- 200, 600, 1000 and 2000 mg/kg
- No. of animals per sex per dose:
- Five
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights - Statistics:
- The acute oral median lethal dose was calculated from the mortality data using logistic regression. Confidence limits were calculated using a likelihood ratio interval (Williams 1986).
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 971 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 758 - 1 245
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 239 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 943 - 1 629
- Mortality:
- Three female and one male animal dosed at 1000 mg/kg died or were killed in extremis on Day 1. All animals dosed 2000 mg/kg died or were killed in extremis on Day 1, and nine out of ten deaths were within the first two hours after dosing.
- Clinical signs:
- other: Significant signs of toxicity were seen in animals dosed at 200 or 600 mg/kg, but all animals had recovered four or five days after dosing. Extreme signs of toxicity (e.g. exophthalmus, piloerection, upward curviture of spine, urinary incontinence, dehydr
- Gross pathology:
- No macroscopic observations were detected at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The substance was found to be acutely toxic to rats after administration by gavage of a single oral dose.
- Executive summary:
The acute oral toxicity of the test substance was investigated under non-GLP in a study similar to an OECD guideline study. The experiment is considered relevant, adequate and conclusive.
Groups of five female and five male Alderley Park SPF albino rats, in the bodyweight range from 198-253 g for females and 221-390 g for males, were fasted for a period of 16 to 24 hours before exposure. Preparations of the test substance, in corn oil, were then dosed at a standard volume of 10 mL/kg. Single doses of 200, 600, 1000 and 2000 mg/kg were administered by gavage to separate groups of animals on Day 1. The animals were observed daily up to Day 15. None of the animals receiving a single dose of 200 or 600 mg/kg died. Three female animals and 1 male animal dosed at 1000 mg/kg died on Day 1. All animals dosed at 2000 mg/kg died on Day 1. Significant signs of toxicity were seen in animals receiving 200 and 600 mg/kg, and extreme signs of toxicity were seen in animals dosed at 1000 or 2000 mg/kg. Surviving animals recovered after four to five days. All animals lost weight initially (due to fasting prior to dosing), but all surviving animals had gained weight at the end of the study. No macroscopic observations were made at necropsy.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.