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EC number: 262-980-8 | CAS number: 61788-49-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 19 October 1956 to 27 December 1956
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Intracutaneous injection of test material in physiological saline on alternate days to a total of ten injections in each of the eight male guinea pigs.
- GLP compliance:
- no
- Remarks:
- investigation took place prior to introduction of GLP
- Type of study:
- intracutaneous test
- Justification for non-LLNA method:
- The study was conducted in 1956, before the requirement to conduct an OECD 429 became mandatory.
Test material
- Reference substance name:
- Hexadecyl acetate
- EC Number:
- 211-103-7
- EC Name:
- Hexadecyl acetate
- Cas Number:
- 629-70-9
- Molecular formula:
- C18H36O2
- IUPAC Name:
- hexadecyl acetate
- Reference substance name:
- Acetic acid, esters with lanolin alcs.
- EC Number:
- 262-980-8
- EC Name:
- Acetic acid, esters with lanolin alcs.
- Cas Number:
- 61788-49-6
- Molecular formula:
- C29H48O2
- IUPAC Name:
- Acetic acid, esters with lanolin alcs.
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: White
- Sex:
- male
- Details on test animals and environmental conditions:
- - Eight, normal, healthy, white male guinea pigs, each weighing 300 to 400 g, were used for the experiment.
- Animals were maintained on a regular diet of rabbit pellets supplemented with spinich and kale throughout the experiment.
- As much hair as possible was removed from the sides and back of each guinea pig with electric clippers.
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal
- Vehicle:
- physiological saline
- Concentration / amount:
- 0.1 % suspension of test material
Challenge
- No.:
- #1
- Route:
- intradermal
- Vehicle:
- physiological saline
- Concentration / amount:
- 0.1 % suspension of test material
- No. of animals per dose:
- Eight
- Details on study design:
- - The test material was made up as a 0.1 % suspension in physiological saline and injected using a 0.25 mL syringe with a 0.5 inch 26 gauge needle.
- Injections were made every other day until a total of ten had taken place.
- The first injection was 0.05 mL while the remaining injections were all 0.1 mL.
- An area consisting of 3-4 cm2 was used for the site of the injection. However, the inital injection was given slightly below the sensitisation area.
- Two weeks after the final injection, a test injection of 0.05 mL of a freshly prepared suspension was administered.
- Reaction readings were made 24 hours after the initial and final 0.05 mL injections. - Positive control substance(s):
- no
Results and discussion
- Positive control results:
- Not applicable
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.1%
- No. with + reactions:
- 8
- Total no. in group:
- 8
- Clinical observations:
- Small raised areas
- Reading:
- rechallenge
- Group:
- test chemical
- Dose level:
- 0.1%
- No. with + reactions:
- 8
- Total no. in group:
- 8
- Clinical observations:
- No effects greater than initial injection
- Remarks on result:
- no indication of skin sensitisation
Any other information on results incl. tables
- Twenty four hours after the initial injection, small raised areas were observed.
- These areas showed a slight increase in colour when compared to the surrounding area.
- The swellings were approximately 4-5 mm in diameter and 3-4 mm in height.
- Fourteen days after the last sensitising injection was given, 0.05 mL of a new 0.1 % suspension showed no greater effects than did the initial injection.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material produced no sensitising effects in the guinea pig.
- Executive summary:
METHOD
A mixture declared to contain 90 % of test item was prepared as a 0.1 % suspension in physiological saline and administered to eight male guinea pigs by intracutaneous injection (initial injection of 0.05 mL in physiological saline followed by injections of 0.1 mL to a total of ten).
RESULTS
Twenty four hours after the initial injection, small raised areas were observed. These areas showed a slight increase in colour when compared to the surrounding area and the swellings were approximately 4-5 mm in diameter and 3-4 mm in height.
Fourteen days after the last sensitising injection was given, 0.05 mL of a new 0.1 % suspension showed no greater effects than did the initial injection.
CONCLUSION
The test material produced no sensitising effects in the guinea pig.
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