Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-129-7 | CAS number: 55552-95-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Remarks on result:
- not determinable
- Details on results:
- As the test item was a liquid, the flask method was considered applicable.
Although the standard EC A.6 / OECD 105 methodology was initially attempted, it was considered after review of the preliminary test analysis and observations that it was not completely applicable to this test item. Therefore, a range of sample concentrations from a nominal 5 to 95% w/w were prepared for visually assessment. The visual assessment of the preliminary test samples was included with those of the definitive test to add extra information and assist in the assessment of the test results. The preliminary test sample concentrations were calculated as % w/w by assuming the 100 mL of water used weighed 100 g.
Up to approximately 25% w/w the observations suggested a majority of the test item dissolved in the water. As the test item was a complex mixture, the undissolved test item was probably mostly comprised of the least soluble components. Up to this concentration, some of the more water soluble components could be essentially fully dissolve. The test guidelines are not ideally suited to determining the water solubility of complex mixture as each component has a governing effect on the other components. As a simplistic description, the most soluble components will aid the dissolution of moderately soluble components which in turn aid the least soluble components; this is a so called “co-solvent effect”.
At higher concentrations, from approximately 50 to 95% w/w, the test item was observed to be miscible with water. At these concentrations there were enough water soluble components to keep all components and the water as a single solution.
From these results, it was evident that water solubility of the test item was loading rate dependent. This was not unexpected as the test item was a complex mixture. Therefore, as the solubility of the test item was loading rate dependent, a single definitive value was not possible. - Conclusions:
- The water solubility of the test item at 20.0 ± 0.5 °C has been demonstrated to be loading rate dependent with at least a majority of the test item dissolving at all loading rates.
As the solubility of the test item was loading rate dependent, a single definitive value was not possible. - Executive summary:
Demonstrated to be loading rate dependent at 20.0 ± 0.5 °C with at least a majority of the test item dissolving at all loading rates, using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
As the solubility of the test item was loading rate dependent, a single definitive value was not possible.
Reference
Sample | Concentration (% w/w) | Observations | Solution pH |
P1 | 0.09 | colorless, clear liquid visually free of excess/undissolved test item | not taken |
P2 | 0.99 | Yellow, clear liquid with excess/undissolved test item | 10.6 |
1 | 5.03 | Amber, clear, non-viscous liquid with small amount of excess/undissolved test item | 10.6 |
P3 | 9.10 | Amber, clear liquid with a small amount of excess/undissolved test item 11.1 2 25.2 11.0 3 49.3 11.4 4 74.8 5 95.0 | 11.1 |
2 | 25.2 | Dark amber, clear, non-viscous liquid with excess/undissolved test item | 11.0 |
3 | 49.3 | Dark amber, clear, non-viscous liquid visually free of excess/undissolved test item | 11.4 |
4 | 74.8 | Amber, clear viscous liquid visually free of excess/undissolved test item | not feasible |
5 | 95.0 | Amber, clear viscous (more so than Sample 4) liquid visually free of excess/undissolved test item | not feasible |
Description of key information
The water solubility of the test item at 20.0 ± 0.5 °C has been demonstrated to be loading rate dependent with at least a majority of the test item dissolving at all loading rates.
As the solubility of the test item was loading rate dependent, a single definitive value was not possible.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.