Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1944
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment (taking into account the publication year)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1944

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
3 different doses: 200 mg/kg , 350 mg/kg , 400 mg/kg
8-16 rats/dose
Intravenous injection
GLP compliance:
no
Remarks:
no GLP at this time

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intravenous
Vehicle:
not specified
Doses:
200 mg/kg
350 mg/kg
400 mg/kg
No. of animals per sex per dose:
200 mg/kg: 16 animals
350 mg/kg: 8 animals
400 mg/kg: 10 animals
Control animals:
not specified
Details on study design:
Succinchlorimide is acid in reaction and must be neutralized.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 200 - < 400 mg/kg bw
Based on:
test mat.
Mortality:
200 mg/kg: 19 % mortality
350 mg/kg: 12 % mortality
400 mg/kg: 90 % mortality

Applicant's summary and conclusion

Conclusions:
Acute toxicity when injected intravenously:
200 mg/kg: 19 % mortality
350 mg/kg: 12 % mortality
400 mg/kg: 90 % mortality
Executive summary:

The acute toxicity of Succinchlorimide was tested when injected intravenously to group of 8 -16 rats. 3 different doses were applied: 200, 350, 400 mg/kg.

Mortalities:

200 mg/kg: 19 % mortality

350 mg/kg: 12 % mortality

400 mg/kg: 90 % mortality