Registration Dossier
Registration Dossier
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EC number: 204-878-8 | CAS number: 128-09-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1944
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment (taking into account the publication year)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 944
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- 3 different doses: 200 mg/kg , 350 mg/kg , 400 mg/kg
8-16 rats/dose
Intravenous injection - GLP compliance:
- no
- Remarks:
- no GLP at this time
Test material
- Reference substance name:
- Succinchlorimide
- IUPAC Name:
- Succinchlorimide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Doses:
- 200 mg/kg
350 mg/kg
400 mg/kg - No. of animals per sex per dose:
- 200 mg/kg: 16 animals
350 mg/kg: 8 animals
400 mg/kg: 10 animals - Control animals:
- not specified
- Details on study design:
- Succinchlorimide is acid in reaction and must be neutralized.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 200 mg/kg: 19 % mortality
350 mg/kg: 12 % mortality
400 mg/kg: 90 % mortality
Applicant's summary and conclusion
- Conclusions:
- Acute toxicity when injected intravenously:
200 mg/kg: 19 % mortality
350 mg/kg: 12 % mortality
400 mg/kg: 90 % mortality - Executive summary:
The acute toxicity of Succinchlorimide was tested when injected intravenously to group of 8 -16 rats. 3 different doses were applied: 200, 350, 400 mg/kg.
Mortalities:
200 mg/kg: 19 % mortality
350 mg/kg: 12 % mortality
400 mg/kg: 90 % mortality
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