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EC number: 237-732-7 | CAS number: 13952-84-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: public study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- The Acute Oral Toxicity of lsomeric Monobutylamines i
- Author:
- Chever K
- Year:
- 1 982
- Bibliographic source:
- Toxicology and applied pharmacology 63, (150-152)
Materials and methods
- Principles of method if other than guideline:
- Male and female weanling Sprague-Dawley CD rats
of the same age were obtained from the Charles River
Breeding Laboratories, Wilmington, Massachusetts.
These animais were housed two per cage and were acclimated
to laboratory conditions for 2 weeks prior to
initiation of the experiment. Laboratory temperatures
ranged from 22 to 26°C, and the relative humidity
ranged from 22 to 49%. A 12-hr light-dark schedulewas maintained with the light cycle beginning at 7:00
AM. Except for an 18-hr period immediately prior to
treatment, the animais were provided with Rodent Laboratory
Chow (Ralston Purina Co., St. Louis, Mo.). Tap
water was available ad libitum.
In a range-finding study, rats were treated in groups
of two males and two females with various amounts of
the test compound. From the resulting mortality data,
a range of doses was
established. Solutions of the monobutylamines were
then prepared in corn oil such that doses of 1 OO, 200,
300, 400, 500, and 600 mg/kg body wt for sec.-butylamine,
could be administered in a constant 4-ml volume.
Upon initiation of the toxicity experiment, the rats
were starved overnight, weighed (males, 194. 7 ± 20. 5
g; females, 156 ± 16.8 g), and randomly assigned to 24
dosage groups, each group consisting of 10 male and 10
female rats. The specified doses of each monobutylamine
were administered, by gavage, to ail rats within the corresponding
dosage groups. These animais were observed
for signs of toxicity or mortality during the subsequent
14-day period, and those that died during this period
were subjected to gross pathological examination. LD,0
values for each monobutylamine were calculated for
both niales and females from the mortality in the several
groups by the probit method of Finney ( 1971 ). - GLP compliance:
- no
Test material
- Reference substance name:
- sec-butylamine
- EC Number:
- 237-732-7
- EC Name:
- sec-butylamine
- Cas Number:
- 13952-84-6
- Molecular formula:
- C4H11N
- IUPAC Name:
- butan-2-amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- These animais were observed
for signs of toxicity or mortality during the subsequent
14-day period, and those that died during this period
were subjected to gross pathological examination. LD,0
values for each monobutylamine were calculated for
both niales and females from the mortality in the several
groups by the probit method of Finney ( 1971 ). - Doses:
- 1 OO, 200,300, 400, 500, and 600 mg/kg body wt for sec.-butylamine
- No. of animals per sex per dose:
- 2 males and 2 females
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 157.5 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 146.8 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 152.4 mg/kg bw
- Based on:
- test mat.
- Mortality:
- sedation, ataxia, nasal
discharge, gasping, salivation, and, at higher
doses, convulsions and death. At the dose
levels tested, death generally occurred within
1 to 3 hr after administration of the amine.
Animais which survived the 14-day period
appeared normal and were not further examined.
Gross pathological examination of
animais that died following treatment showed pulmonary edema - Clinical signs:
- other: sedation, ataxia, nasal discharge, gasping, salivation, and, at higher doses, convulsions and death. At the dose levels tested, death generally occurred within 1 to 3 hr after administration of the amine. Animais which survived the 14-day period appeared
Any other information on results incl. tables
sec.-Butylamine LD (50) slope (+/_ SD)
M 157.5 ( 35.1 -242.8) 1.89 (±0.67)
F 146.8 (12.4-239.3) 1.67 (±0.66)
M and F 152.4 (69.3-214.8) 1.78 (±0.47)
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Sec butylamine is toxic after oral ingestion in rats.
- Executive summary:
The LD50 values for the substance was calculated by the probit method.
No significant sex-related differences were noted. The 14-day, po single-dose
LD50 values (mg/kg body wt) were: for male, 157.5 mg/kg, and for female, 146.8 mg/kg.
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