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EC number: 214-014-1 | CAS number: 1072-71-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-10-05 - 2016-10-12 (experimental phase); 2016-08-18 - 2016-11-24 (study initiation - final report)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hess. Ministerium für Umwelt, Energie, Landwirtschaft und Verbraucherschutz, Mainzer Straße 80, D65189 Wiesbaden, Germany
- Specific details on test material used for the study:
- The test item was tested as received. No further preliminary treatment such as drying or milling was performed.
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: only parent: upon preparation and day 5
- Sampling method: aliquots were taken
- Sampling intervals/times for pH measurements: upon preparation and day 5
- Other observation, if any (e.g.: precipitation, color change etc.): none stated - Buffers:
- - pH: 4, 7, 9
pH 4:
21.01 g citric acid monohydrate was dissolved in 200 ml sodium hydroxide solution (c = 1 mol/l). This solution was filled up to a volume of 1000 ml with demineralized water. 44 ml of hydrochloric acid (c = 1 mol/l) was added to 560 ml of this solution and filled up to a volume of 1000 ml with demineralized water. The pH value of the buffer solution was adjusted to pH 4 with hydrochloric acid or sodium hydroxide solution for each hydrolysis temperature.
pH 7:
13.61 g potassium dihydrogen phosphate was dissolved in 1000 ml demineralized water. 30 ml of sodium hydroxide solution (c = 1 mol/l) was added to 500 ml of this solution and filled up to a volume of 1000 ml with demineralized water. The pH of the buffer solution value was adjusted to pH 7 with hydrochloric acid or sodium hydroxide solution for each hydrolysis temperature.
pH 9:
7.46 g potassium chloride and 6.18 g boric acid were dissolved in 1000 ml demineralized water. 21 ml of sodium hydroxide solution (c = 1 mol/l) was added to 500 ml of this solution and filled up to a volume of 1000 ml with demineralized water. The pH value of the buffer solution was adjusted to pH 9 with hydrochloric acid or sodium hydroxide solution for each hydrolysis temperature. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 50 ml
- Sterilisation method: The used volumetric flasks are baked out at 110 °C and flooded with nitrogen. Solutions of the test item are prepared in the relevant buffers. The standards for calibration and recheck are freshly prepared.
TEST MEDIUM
- Volume used/treatment
- Kind and purity of water: demineralized water
- Preparation of test medium: The test item is added as an aqueous solution into the different buffer solutions (pH 4, 7 and 9). The concentration of the solution should not exceed 0.01 M or half of the saturation concentration of the test item. If it is necessary for adequate dissolution, the use of low amounts of water miscible solvents (such as acetonitrile, acetone, ethanol) is permitted as solubilizer for the test item but this should not normally exceed 1 % v/v. - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 488.5 - <= 586.5 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 431.9 - <= 504.2 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 484.1 - <= 599.2 mg/L
- Number of replicates:
- 2 per pH
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- Table: Results of the preliminary test (experiments 1 to 6)
Experiment pH of buffer solution pH of test item solution Duration in d c0 / mg/l ct / mg/l ct / c0 Decomposition / %
1 4.0 4.0 5 488.5 472.9 0.968 3.2
2 4.0 4.0 5 586.5 495.6 0.848 15.5
3 7.0 7.0 5 504.2 520.6 1.033 -3.3
4 7.0 7.1 5 431.9 417.5 0.967 3.3
5 9.0 9.1 5 484.1 467.9 0.967 3.4
6 9.0 9.1 5 599.2 582.6 0.972 2.8
Experiment 2 showed an unusual deviation compared to the other five experiments. As there was no further indication (e.g. instable standard solutions) that the test item is not hydrolytic stable, this experiment was not taken into account for further evaluations. The deviation may be caused by a dilution error.
At pH 4, 7 and 9 less than 10 % of the test item hydrolysed within 5 days, therefore the test item was hydrolytically stable. No additional testing (Tier 2 and 3) was required. - Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- n/a
- % Recovery:
- 96.8
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- 100
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- 96.9
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Remarks:
- 3.2% decomposition
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Remarks:
- 0.0% decomposition
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Remarks:
- 3.1% decomposition
- Details on results:
- TEST CONDITIONS
- Anomalies or problems encountered (if yes): Experiment 2 showed an unusual deviation compared to the other five experiments. As there was no further indication (e.g. instable standard solutions) that the test item is not hydrolytic stable, this experiment was not taken into account for further evaluations. The deviation may be caused by a dilution error. - Validity criteria fulfilled:
- not specified
- Conclusions:
- The study was performed according to OECD TG 111 with no deviations, the results were so obtained via a scientifically reasonable method. Hence, there is no doubt that the obtained results are not reliable: At pH 4, 7 and 9 and at 50±0.5°C less than 10 % of the test item hydrolysed within 5 days, therefore the test item was hydrolytically stable. No additional testing (Tier 2 and 3) was required. This conclusion is in congruence with the stipulations set out in OECD TG 111, no further testing, i.e. determination of the hydrolysis rate and products is required, as the substance is stable.
- Executive summary:
Hydrolysis of 2,5-Dimercapto-1,3,4-thiadiazole at ca 431.9-599.2 mg/L was studied at 50ºC in sterile aqueous buffered solutions at pH 4, pH 7 and pH 9 for 5 days. The experiment was conducted in accordance with EU method C.7 and OECD TG 111, and in compliance with GLP. Samples were analysed at 0 and 5 days, and the test material was analysed by HPLC/UV-Vis.
At pH 4, 7 and 9 less than 10 % of the test item hydrolysed within 5 days, therefore the test item was hydrolytically stable. No additional testing (Tier 2 and 3) was required. This study is classified acceptable and satisfies the guideline requirement for hydrolysis study.
Reference
Description of key information
Hydrolysis: hydrolytically stable, at pH 4, 7 and 9 less than 10 % of the test item hydrolysed within 5 days at 50°C (OECD 111, GLP)
Key value for chemical safety assessment
Additional information
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