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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
Deviations:
no
GLP compliance:
yes
Remarks:
without certificate
Type of method:
sieving
Type of particle tested:
primary particle
Type of distribution:
mass based distribution
Mass median aerodynamic diameter:
7.04 µm
No.:
#1
Size:
< 4 µm
Distribution:
0.41 %
Remarks on result:
other: sperical volume
No.:
#1
Size:
>= 4 - <= 10 µm
Distribution:
25.37 %
Remarks on result:
other: sperical volume
No.:
#1
Size:
>= 10 - <= 100 µm
Distribution:
74.22 %
Remarks on result:
other: sperical volume

Result: Sieve Fraction (< 100 µm):

weighted sample: 1.2033 g

weight fraction < 100 µm: 0.0006 g

mass fraction < 100 µm: 0.05 %

Statistical data:

 Counts  1696  
   Mean diameter [µm]  Aspect ratio
 Minimum  3.10  1.05
 Maximum  24.67  2.99
 Arithmetic mean  8.01  1.94
 Median  7.02 1.87 
Standard deviation   3.63  0.49

Statistical Data Mass Fraction:

 Particle Size  Sperical Volume [%]  Cubical Volume [%]
 < 4 µm (respirable)  0.41  0.68
 4 -10 µm (thoracic)  25.37  27.37
 10 -100 µm (inhalable)  74.22 71.95 
 > 100 µm  0.00  0.00
 Median (diameter µm)  7.04

7.43 

Median diameter corresponds to MMAD (Mass Median Aerodynamic Diameter)

Conclusion: Accounting based on total sample weight

   Particle Size [µm]  Sperical Volume [%]
 Mass Fraction  > 100  99.95
 Sieve Fraction  > 100  0.00
 Total (> 100 µm)    99.95
 Sieve Fraction  10 -100 (inhalable)  0.04
 Sieve Fraction  4 -10 (thoracic)  0.01
 Sieve Fraction  < 4 (respirable)  0.00

The MMAD (Mass Median Aerodynamic Diameter < 100 µm) has a value of 7.04 µm as sperical particles.

Conclusions:
The MMAD (Mass Median Aerodynamic Diameter < 100 μm) of Dihydrochinizarin has a value of 7.04 μm as spherical particles.
Executive summary:

Determination of the particle size distribution of Dihydrochinizarin was determined by scanning electron microscopy after the samples was fractionated by a 100 μm sieve following OECD Guidelines No: 110 method B. For the determination of the particle size and the aspect ratio, 3 pictures have been taken by SEM (scanning electron microscop) at a magnification of 430 times. The MMAD (Mass Median Aerodynamic Diameter < 100 μm) has a value of 7.04 μm as spherical particles.

Description of key information

The MMAD (Mass Median Aerodynamic Diameter < 100 μm) of Dihydrochinizarin has a value of 7.04 μm as spherical particles.

Additional information