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EC number: 288-098-3 | CAS number: 85650-88-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-01-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-(carboxylatomethyl)dimethylpyridinium
- EC Number:
- 285-926-5
- EC Name:
- 1-(carboxylatomethyl)dimethylpyridinium
- Cas Number:
- 85168-84-9
- Molecular formula:
- C9H11NO2
- IUPAC Name:
- (2,3-dimethylpyridinium-1-yl)acetate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Nottingham University, School of Agriculture, Sutton Bonington, Leicestershire, U. K.
- Age at study initiation: approx. 12 to 16 weeks
- Weight at study initiation: 2.30 - 2.59 kg
- Housing: The animals were individually housed in suspended metal cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: min 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 18 - 21 °C
- Humidity: 45 - 60 %
- Air changes: approx. 15 per hr
- Photoperiod: 12 / 12hrs dark / hrs light
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- Approximately one hour following removal of the patches, and 24, 48 and 72 hours later, the test sites were examined for evidence of prirnary irritation and scored.
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: dorsal flank area
- % coverage: 2.5 cm x 2.5 cm gauze patch, whole trunk wrapped
- Type of wrap: adhesive strapping (SLEEK) wrapped with elasticated corset (TUBIGRIP)
REMOVAL OF TEST SUBSTANCE
- Washing: gentle swabbing with cotton wool soaked in distilled water.
- Time after start of exposure: 4 h
OBSERVATION TIME POINTS : Approximately one hour following removal of the patches, and 24, 48 and 72 hours later.
SCORING SYSTEM:
- Method of calculation: Draize J.H. (1959) Association of Food and Drug 0ffi ci al s of the Uni ted States, Austi n, Texas, "The Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- No signs of skin irritation were noted during the study period. The test material was therefore considered as non irritant.
Any other information on results incl. tables
Table 1 Individual daily and individual mean scores for dermal irritation/corrosion
Animal no |
Time after treatment |
Erythrema/Eschar |
Oedema Formation |
1 |
1 |
0 |
0 |
24 |
0 |
0 |
|
48 |
0 |
0 |
|
72 |
0 |
0 |
|
Total 24, 48, 72 h |
0.0 |
0.0 |
|
2 |
1 |
0 |
0 |
24 |
0 |
0 |
|
48 |
0 |
0 |
|
72 |
0 |
0 |
|
Total 24, 48, 72 h |
0.0 |
0.0 |
|
3 |
1 |
0 |
0 |
24 |
0 |
0 |
|
48 |
0 |
0 |
|
72 |
0 |
0 |
|
Total 24, 48, 72 h |
0.0 |
0.0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item was found to be non-irritant to the rabbit skin under the conditions of this study.
- Executive summary:
The study was carried out in order to assess the irritancy potential of a test material following a single 4-hour semi-occluded application to the intact rabbit skin. The study was designed to comply with the recommendations of the OECD Guidelines for Testing of Chemicals (1981) No.404 "Acute Dermal Irritation/Corrosion". The test system was chosen because the rabbit has been shown to be a suitable model for this type of study and is recommended by the test method. Three New Zealand White rabbits were exposed to the test item on the clipped skin under semiocclusive dressing. After 4 h the test item was removed by gentle washing. Skin was inspected for local irritaion symptons directly after removing the test item and after 24, 48, and 72 h. No signs of skin irritation were noted during the study period. Therefore, the test item is considered to be not irritating to rabbit skin.
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