Registration Dossier
Registration Dossier
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EC number: 212-975-1 | CAS number: 894-93-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- intramuscular injection
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Antitumor activities of some Schiff bases
- Author:
- Hodnett, Ernest M.; Mooney, Paul D.
- Year:
- 1 970
- Bibliographic source:
- Journal of Medicinal Chemistry (1970) Vol. 13, No. 4, pp. 786.
Materials and methods
- Principles of method if other than guideline:
- Single intramuscular injection to Walker sarcomas of rats
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-[[(2-hydroxyphenyl)imino]methyl]-2-naphthol
- EC Number:
- 212-975-1
- EC Name:
- 1-[[(2-hydroxyphenyl)imino]methyl]-2-naphthol
- Cas Number:
- 894-93-9
- Molecular formula:
- C17H13NO2
- IUPAC Name:
- 1-[(1E)-[(2-hydroxyphenyl)imino]methyl]naphthalen-2-ol
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- intramuscular
- Doses:
- 400 mg/kg bw
Results and discussion
- Mortality:
- Not specifically mentioned. Since the dose was used to determine antitumor-activity, it is presumed to be non-lethal.
- Other findings:
- Tumor size was reduced to 78% after injection with the test substance.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
