Formamide, N-[(2-bromo-5-hydroxy-4-methoxyphenyl)methyl]-N-[2-(4-hydroxyphenyl)ethyl]-

Explosiveness

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

explosive properties of explosives

Type of information:

other: Expert statement

Adequacy of study:

supporting study

Study period:

2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Expert statement following no specific guideline and without detailed description of results.

Qualifier:

no guideline followed

Principles of method if other than guideline:

Expert statement.

GLP compliance:

no

Specific details on test material used for the study:

- Batch n°: I15EB1917
- Analytical purity: 98.9%
- Expiration date: 2017-09-07
- Storage condition: at room temperature

None of the components of the test item does contain chemical groups which are associated with explosive properties. The molecular structures of impurities present at =< 1% were not taken into account.

In conclusion, JNJ-28645409-AAA (T002078) has no explosive properties.

Interpretation of results:

GHS criteria not met

Conclusions:

It is concluded that the substance JNJ-28645409-AAA (T002078) does not have explosive properties.

Reference 2

Endpoint:

explosive properties of explosives

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: The test is performed according to EC guideline with some small deviations. However, there is no information on purity of the substance.

Qualifier:

according to guideline

Guideline:

EU Method A.14 (Explosive properties)

Deviations:

yes

Remarks:

1)The weight of the falling hammer is 5 kg and dropped from 0.8 m, however, the energy applied is the same as guideline, 40 J or 40 Nm. 2) In contrast to the EC guideline aluminium foil is used to pack the substance. 3) Ten tests are performed.

GLP compliance:

not specified

Parameter:

other: More sensitive to shock than m-dinitrobenzene

Remarks on result:

negative (not further specified)

Remarks:

If all tests according to Lütolf method are negative, powder can be considered not shock sensitive as reference substance meta-dinitrobenzene is not shock sensitive in similar conditions (although not tested simultaneously in this study)

Results:

-10 times negative not shock sensitive (sensitivity > 39.2 Nm)

Interpretation of results:

non explosive

Conclusions:

The test substance is not shock sensitive.

Description of key information

Based on an expert statement (Brekelmans, 2017), T002078 is considered not to contain any chemical groups indicative of explosive properties. Further testing was not required and T002078 is concluded not to have explosive properties.

Key value for chemical safety assessment

Explosiveness:

non explosive

Additional information

A study of which the reliability was not assignable (K4, Janssen Pharmaceutica Process Safety Center, 1997) concluded that the test substance is not shock sensitive (sensitivity > 39.2 Nm) (Lütolf method). This study supports the conclusions of the expert statement.

Justification for classification or non-classification

T002078 does not need to be classified as explosive as based on the chemical structure T002078 does not contain any chemically instable or highly energetic groups that might lead to an explosion.